Screening for cardiovascular comorbidity in United States outpatients with psoriasis, hidradenitis, and atopic dermatitis

Singh, Partik; Silverberg, Jonathan I.

doi:10.1007/s00403-020-02087-w

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…Firstly, increased BP screening is warranted in patients with AD, especially in those with moderate‐to‐severe disease. However, previous studies found that BP screening was performed significantly less commonly in patients with AD or psoriasis vs. without them 100 . Our results underscore the need for increased BP screening in patients with AD.…”

Section: Discussionsupporting

confidence: 59%

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Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

et al. 2021

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Background Previous studies have found conflicting results about the association of atopic dermatitis (AD) with hypertension. Objectives To determine whether AD and AD severity are associated with hypertension. Methods A systematic review was performed of published studies in Ovid MED-LINE, Embase, Scopus, Web of Science, and GREAT (Global Resource for EczemA Trials) databases. At least two reviewers conducted title/abstract, full-text review and data extraction. Quality of evidence was assessed using the Newcastle-Ottawa Scale.Results Fifty-one studies met the inclusion criteria and 19 had sufficient data for meta-analysis. AD was associated with higher odds of hypertension compared with healthy controls [increased in nine of 16 studies; pooled prevalence 16Á4% vs. 13Á8%; random-effects regression, pooled unadjusted odds ratio (OR) 1Á16, 95% confidence interval (CI) 1Á04-1Á30], but lower odds of hypertension compared with psoriasis [decreased in five of eight studies; 15Á4% vs. 24Á8% (OR 0Á53, 95% CI 0Á37-0Á76)]. In particular, moderate-to-severe AD was associated with hypertension compared with healthy controls [increased in four of six studies; 24Á9% vs. 14Á7% (OR 2Á33, 95% CI 1Á10-4Á94)]. Hypertension was commonly reported as an adverse event secondary to AD treatments, particularly systemic ciclosporin A. Limitations include lack of longitudinal studies or individual-level data, and potential confounding. Conclusions AD, particularly moderate-to-severe disease, was associated with increased hypertension compared with healthy controls, but with lower odds than for psoriasis.What is already known about this topic?• Previous studies have showed conflicting results regarding the association between atopic dermatitis (AD) and hypertension.

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Section: Discussionsupporting

confidence: 59%

“…However, previous studies found that BP screening was performed significantly less commonly in patients with AD or psoriasis vs. without them. 100 Our results underscore the need for increased BP screening in patients with AD. However, dermatologists or allergists are often the only providers patients with AD see, i.e.…”

Section: Discussionsupporting

confidence: 55%

Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

et al. 2021

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“…Some of their recommendations included the importance of educating front-line providers about HS 32 . They also emphasized establishing a strong channel of communication between dermatologists and front-line providers, establishing HS specialty clinics, implementing rotations for medical students and residents, creating and moderating virtual or local HS support groups, establishing a multidisciplinary/multispecialty approach to manage the many associated comorbidities 33 of HS ( Figure 1 ), providing education in wound care to both clinic staff and patients, working with infusion clinics to facilitate the administering of intravenous treatment, screening frequently for depression, anxiety, and suicidality, and staying up to date on new therapeutics and ongoing clinical trials for HS 34 . In addition, cigarette smoking is a known trigger of HS, and thus smoking cessation is recommended as it potentially improves HS as well as other health outcomes 1 .…”

Section: Treatment Optionsmentioning

confidence: 99%

The most recent advances in understanding and managing hidradenitis suppurativa

2020

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Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, and debilitating skin disease of the hair follicle unit that typically develops after puberty. HS has a significant negative impact on both the quality of life (QOL) of patients affected by this disease as well as family members and caregivers. However, the pathogenesis of HS is multifactorial and still remains to be fully elucidated, which makes the development of treatments difficult. The last 10 years have seen a surge in HS research, and many new findings have come to light, yet much more remains to be elucidated. Physicians must employ a multidisciplinary approach to maximally address all facets of HS. Clinical characteristics of the disease that differ between females and males as well as across different races and ethnic groups must be considered. Targeted topical, oral, and injectable therapies continue to be developed for HS as a greater understanding of the pathogenesis is reached. However, randomized controlled trials regarding dietary factors that may contribute to HS are needed to meet our patients’ growing concerns and questions about the role of diet in HS pathogenesis. Finally, improved outcome measures are needed to standardize HS severity and grading between physicians and clinical trials, and a more diverse representation of HS populations is needed in clinical trials.

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“…In conclusion, patients with HS should be informed of their increased risk of MACEs. Because of the suboptimal screening for cardiovascular comorbidities in patients with HS, 5 early screening and appropriate counseling on modifiable cardiac risk factors should be provided for all patients with HS, and appropriate cardiac workup should be considered in those presenting with cardiac symptoms.…”

Section: Hidradenitis Suppurativa and Major Adverse Cardiac Events: A Systematic Review And Meta-analysismentioning

confidence: 99%

Hidradenitis suppurativa and major adverse cardiac events: A systematic review and meta-analysis

Bailey

Tan

et al. 2021

Journal of the American Academy of Dermatology

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Screening for cardiovascular comorbidity in United States outpatients with psoriasis, hidradenitis, and atopic dermatitis

Cited by 14 publications

References 16 publications

Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

The most recent advances in understanding and managing hidradenitis suppurativa

Hidradenitis suppurativa and major adverse cardiac events: A systematic review and meta-analysis

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