Screening for bipolar spectrum disorders: A comprehensive meta-analysis of accuracy studies

Abstract

Although accuracy properties of the three screening instruments did not consistently differ in mental health care services, the HCL-32 was more accurate than the MDQ for the detection of type II BD. More studies in other settings (for example, in primary care) are necessary.

Childhood interleukin-6, C-reactive protein and atopic disorders as risk factors for hypomanic symptoms in young adulthood: a longitudinal birth cohort study

“…It also asks about the duration of such episodes and their impact on family, social and work life. The HCL-32 has been used as both a continuous and categorical measure of hypomanic symptoms (Court et al 2014;Carvalho et al 2015). Although initially developed as a screening instrument for use in people diagnosed with depressive disorders, it is also a sensitive screening tool in non-clinical settings (Meyer et al 2007).…”

“…There have not yet been sensitivity and specificity tests of the HCL-32 as a categorical measure which includes duration and impact on functioning. However, it is likely that by including questions on these features we have improved sensitivity for a diagnosis of hypomania compared with methods which have previously relied solely on a recommended (arbitrary) cut-off of endorsing 14 from the 32 mood questions (Carvalho et al 2015). It is also unlikely that false positives would occur differentially for different tertiles of IL-6 or CRP, or by asthma/eczema diagnosis.…”

Screening for bipolar disorders: A public health issue

“…Using the MDQ, a US survey found a (lifetime) prevalence of positivity at screening of slightly under 4% (Hirschfeld et al, 2003); in Australia the prevalence was 2.5% (Fisher et al 2007); in Italy 3% (Carta et al, 2012) and in France 3.6% (Carta et al 2013). The HCL-32, which is more complex but more accurate in identifying Bipolar 2 Disorders (Carta et al 2006;Carvalho et al 2014), has been widely used in clinical studies on undiagnosed bipolar disorders (Richardson & Garavan H 2009;Angst et al 2011;Mosolov et al 2014). …”

Detección del riesgo para los trastornos del espectro bipolar: evidencias de validez del Mood Disorder Questionnaire en adolescentes y adultos jóvenes

“…Estos resultados evidencian que la identificación e intervención temprana de los síntomas y experiencias (hipo)maníacos en la población general o en grupos de alto riesgo, así como en contextos asistenciales y clínicos, sería una tarea relevante 8,17 . Ayudar a los profesionales de la salud en la detección precoz de este conjunto de experiencias, tanto a nivel clínico como a nivel subumbral, es una meta sumamente interesante con claras implicaciones prácticas 3,18 .…”