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“…The loss of WRN protein function causes genomic instability, resulting in the accumulation of somatic mutations, aberrant maintenance of telomeres which may lead to cellular dysfunction, loss of proliferative homeostasis, or increased cellular loss in various tissues or cell lines. These cellular changes are probably responsible for the clinical characteristics of early aging and tumor development observed in WS patients [6, 9].…”
Section: Introductionmentioning
confidence: 99%
“…The loss of WRN protein function causes genomic instability, resulting in the accumulation of somatic mutations, aberrant maintenance of telomeres which may lead to cellular dysfunction, loss of proliferative homeostasis, or increased cellular loss in various tissues or cell lines. These cellular changes are probably responsible for the clinical characteristics of early aging and tumor development observed in WS patients [6, 9].…”
Section: Introductionmentioning
confidence: 99%