<scp>TWEAK</scp> and <scp>NT</scp>‐pro<scp>BNP</scp> levels predict exercise capacity in hypertrophic cardiomyopathy

Hernández-Romero, Diana; Jover, Eva; Martínez, Carlos; Andreu-Cayuelas, José M.; Orenes‐Piñero, Esteban; Romero‐Aniorte, Ana I.; Casas, Teresa; Cánovas, Sergio; Montero-Argudo, José A.; Valdés, Mariano; Morena, Gonzalo de la; Marı́n, Francisco

doi:10.1111/eci.12394

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…NT-proBNP is an important indicator for the diagnosis and prognosis of heart failure, left ventricular systolic dysfunction, and left ventricular hypertrophy [11]. HHD resulting from a long-term elevated level of serum thyroxine aggravates in rat myocardium over time manifesting initially as increased myocardial contractility, followed by a decline in the myocardial functions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Schisandra chinensis on the Myocardium of Rats with Hyperthyroid Heart Disease by Using Velocity Vector Imaging Combined with the Estimation of p53 Expression and Calmodulin Activity

Huang

Jin

Gao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Schisandra chinensis (SC) is reported to improve myocardial ischemia. Velocity vector imaging (VVI) is a noninvasive technique for evaluating myocardial function in humans, while few reported on the application in animals. In this study, we aimed to evaluate the improved effects of SC on the myocardium of Sprague Dawley rats having hyperthyroid heart disease (HHD) using VVI technique. HHD models were established by injecting daily with subcutaneous levothyroxine (0.5 mg/kg). Then, the SC group was administered the aqueous extract of SC (2 g/kg) once daily, while the HHD and control (CON) groups were administered the same amount of distilled water daily. All the rats were provided the same amount of food and water daily, and the intervention was stopped after 28 days. The efficacy of SC in HHD rats was evaluated by ultrasound VVI. The serum total triiodothyronine level, total thyroxine level, N-terminal pro-brain natriuretic peptide expression, p53 expression, and calmodulin (CaM) activity were assessed by western blotting, Hematoxylin-Eosin and Masson staining, and electron microscopy. The results indicated that SC significantly improved the systolic velocity, diastolic velocity, strain, systolic strain rate, and diastolic strain rate of the heart by significantly reducing p53 expression and CaM activity (P<0.05), improving myocardial fibrosis in HHD rats. Also, VVI can be a valuable tool for the evaluation of myocardial function in HHD rats.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Schisandra chinensis on the Myocardium of Rats with Hyperthyroid Heart Disease by Using Velocity Vector Imaging Combined with the Estimation of p53 Expression and Calmodulin Activity

Huang

Jin

Gao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Relevance of pre-analytical blood management on the emerging cardiovascular protein biomarkers TWEAK and HMGB1 and on miRNA serum and plasma profiling

Basso

Padoan

Laufer

et al. 2017

Clinical Biochemistry

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High-sensitive cardiac Troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy

Zhang

Gao

Cui

et al. 2023

Preprint

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Background: Apical hypertrophic cardiomyopathy (AHCM) is a subtype of hypertrophic cardiomyopathy (HCM). The expression level of high-sensitive cardiac troponin T (hs-cTNT) and N-terminal pro-BNP (NT-proBNP) in AHCM patients, and these relationships between echocardiography parameters were still unclear. Methods: We retrospectively screened AHCM patients between January 2019 and December 2021 in Zhongshan Hospital Fudan University. The relationship between the level of hs-cTNT, NT-proBNP and echocardiography parameters were analyzed. The risk factors for elevated hs-cTNT and NT-proBNP level were investigated with linear regression analysis. Results: A total of 267 AHCM patients were enrolled. They were divided into hs-cTNT normal (129, 48.3%) and abnormal (138, 51.7%) group. Compared with hs-cTNT normal group, hs-cTNT abnormal group were elder (68.3±11.6 vs. 63.8±10.6, P=0.001); with higher rate of atrial fibrillation (AF) (41.3% vs. 17.8%, P<0.001) and higher level of NT-proBNP concentration (752.0 [343.8-1345.5] vs. 249.0 [104.0-541.0], P<0.001). For echocardiography parameters, hs-cTNT abnormal patients have thicker interventricular septum (IVS) (11.6±2.0 vs. 11.0±1.7, P=0.02), thicker left ventricular apical (LVA) (16.9±3.0 vs. 14.9±2.3, P<0.001) and larger left atrium diameter (LAD) (45.9±6.6 vs. 42.4±5.1, P<0.001). LVA was independently correlated with both the level of hs-cTNT and NT-proBNP (hs-cTNT r=0.224, P=0.143; NT-proBNP r=0.370, P<0.001). Linear regression analysis revealed that LVA was independent risk factor of both the elevated hs-cTNT and NT-proBNP level. Conclusion: More than half of AHCM patients had abnormal hs-cTNT level. LVA was positively and independently correlated with the level of hs-cTNT and NT-proBNP.

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TWEAK and NT‐proBNP levels predict exercise capacity in hypertrophic cardiomyopathy

Abstract: TWEAK and NT-proBNP levels are biomarkers of disease severity independently associated with the effort capacity in patients with HCM.

Cited by 5 publications

References 26 publications

Evaluation of the Effects of Schisandra chinensis on the Myocardium of Rats with Hyperthyroid Heart Disease by Using Velocity Vector Imaging Combined with the Estimation of p53 Expression and Calmodulin Activity

Evaluation of the Effects of Schisandra chinensis on the Myocardium of Rats with Hyperthyroid Heart Disease by Using Velocity Vector Imaging Combined with the Estimation of p53 Expression and Calmodulin Activity

Relevance of pre-analytical blood management on the emerging cardiovascular protein biomarkers TWEAK and HMGB1 and on miRNA serum and plasma profiling

High-sensitive cardiac Troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy

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