<scp>SP1</scp>‐induced <scp>lncRNA DANCR</scp> contributes to proliferation and invasion of ovarian cancer

Cui, Penghua; Li, Zhiyan; Li, Dahai; Han, Shuyu; Zhang, Yujuan

doi:10.1002/kjm2.12316

Cited by 17 publications

(8 citation statements)

References 32 publications

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“…It has been shown [ 19 ] that SP1 acts as a transcription factor, can manipulate a signaling pathway for ovarian cancer progression, and has obvious oncogenic effects. Moreover, SP1 expression is aberrant in many cancers and is associated with poor prognosis [ 20 ] such as in thyroid, gastric, pancreatic, lung, and breast cancers.…”

Section: Discussionmentioning

confidence: 99%

Circ0005654 as a new biomarker of thyroid cancer interacting with SP1 to influence the prognosis: A case-control study

Yang¹,

Cao²,

Zheng-wu

et al. 2023

Medicine

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Circular RNAs (CircRNAs) have been reported to play key roles in the progression of various cancers, including thyroid cancer (TC). Transcription factor 1 (SP1) promotes the development of thyroid cancer. This study aims at investigating the expression level of Circ0005654 in combination with Transcription factor1 (SP1) in patients with TC for diagnostic and therapeutic purposes. A total of 76 patients with thyroid cancer underwent radical surgery. Intraoperatively, thyroid cancer tissues and paired adjacent tissues and the corresponding clinicopathological data were collected. The expression of SP1 and β-catenin in thyroid cancer and adjacent tissues was determined by immunohistochemistry (IHC) while the Circ0005654 expression level was measured by semiquantitative real-time polymerase chain reaction (sqRT-PCR). Then, we compared the variability of Circ0005654, SP1, and Wnt/β-catenin expression in cancerous and adjacent tissues and determined the relationship between the correlation analysis and the clinicopathological features of the thyroid cancer patients. The diagnostic value of Circ0005654 in thyroid cancer tissues was analyzed with the help of the receiver operating characteristic (ROC) curve, counting the 3-year postoperative survival rate, and analyzing the effect of Circ0005654 and SP1 protein levels on the 3-year survival rate of the patients. sqRT-PCR showed that the expression level of Circ0005654 in thyroid cancer tissue was significantly higher than that of adjacent tissues. The area under the ROC of Circ0005654 was 0.9553, 95% confidence interval: (0.9211−0.9895) with a cutoff value of 0.7895, a sensitivity of 92.11%, and a specificity of 86.84%. The IHC results showed that the expression level of SP1, β-catenin, and Wnt was higher in cancer tissues than in adjacent tissues; Circ0005654, SP1, Wnt/β-catenin expression levels were associated with tumor diameter, lymph node metastasis, TNM stage, and envelope invasion (all P < .05). According to the Circ0005654 expression level in thyroid cancer tissue, the 3-year survival rate of the high expression group was 77.5% and 94.4% in the low expression group with a statistically significant difference; the 3-year survival rate of SP1 positive and negative patients was 78.6% and 100%, respectively, with the data being significantly different. Circ0005654 may serve as a potential biomarker for thyroid cancer diagnosis and may be involved in the development of thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Circ0005654 as a new biomarker of thyroid cancer interacting with SP1 to influence the prognosis: A case-control study

Yang¹,

Cao²,

Zheng-wu

et al. 2023

Medicine

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“…SP1 has been described as a promising oncogene in multiple human malignancies, which exerts strong promoting effects on cancer growth, metastasis, and even chemoresistance 25,26 . For instance, in ovarian cancer, SP1 promotes LncRNA‐DANCR‐induced tumor cell proliferation through a direct transcriptional activation 27 28 .…”

Section: Discussionmentioning

confidence: 99%

“… 25 , 26 For instance, in ovarian cancer, SP1 promotes LncRNA‐DANCR‐induced tumor cell proliferation through a direct transcriptional activation. 27 In colon cancer, SP1 induces drug resistance to 5‐Fu via modulating the members of the Mitogen‐actived protein kinase (MAPK) signaling pathway. 28 There is also some evidence supporting the tumor improvement caused by SP1 in HCC.…”

Section: Discussionmentioning

confidence: 99%

E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA‐383‐5p transcription

Hao

Wang

Zhang

et al. 2022

Molecular Carcinogenesis

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“…According to GENCODE, more than 56,000 lncRNA transcripts in almost 19,000 genes have been identified in humans [ 30 ]. Recent evidence suggests that lncRNAs are implicated in several cancer progression mechanisms including proliferation [ 31 , 32 ], differentiation [ 33 , 34 ], autophagy [ 35 , 36 ], epithelial–mesenchymal transition (EMT) [ 37 ], invasion [ 38 , 39 , 40 ], and metastasis [ 41 , 42 ]. LncRNAs are often found as modulators of signaling cascades at the epigenetic, transcriptional, posttranscriptional, translational, or posttranslational levels [ 43 ].…”

Section: Overview Of Long Non-coding Rnasmentioning

confidence: 99%

Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance

Peña-Flores

Enríquez-Espinoza

Muela-Campos

et al. 2023

ncRNA

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Cancer is responsible for more than 10 million deaths every year. Metastasis and drug resistance lead to a poor survival rate and are a major therapeutic challenge. Substantial evidence demonstrates that an increasing number of long non-coding RNAs are dysregulated in cancer, including the long intergenic non-coding RNA, regulator of reprogramming (linc-ROR), which mostly exerts its role as an onco-lncRNA acting as a competing endogenous RNA that sequesters micro RNAs. Although the properties of linc-ROR in relation to some cancers have been reviewed in the past, active research appends evidence constantly to a better comprehension of the role of linc-ROR in different stages of cancer. Moreover, the molecular details and some recent papers have been omitted or partially reported, thus the importance of this review aimed to contribute to the up-to-date understanding of linc-ROR and its implication in cancer tumorigenesis, progression, metastasis, and chemoresistance. As the involvement of linc-ROR in cancer is elucidated, an improvement in diagnostic and prognostic tools could promote and advance in targeted and specific therapies in precision oncology.

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SP1‐induced lncRNA DANCR contributes to proliferation and invasion of ovarian cancer

Cited by 17 publications

References 32 publications

Circ0005654 as a new biomarker of thyroid cancer interacting with SP1 to influence the prognosis: A case-control study

Circ0005654 as a new biomarker of thyroid cancer interacting with SP1 to influence the prognosis: A case-control study

E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA‐383‐5p transcription

Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance

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