<scp>PAK</scp>1‐cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin‐13

Lv, Deguan; Li, Lanfang; Lu, Qixuan; Yao, Li; Xie, Feng; Li, Hening; Cao, Jun; Liu, Meiqing; Wu, Di; He, Lu; Chen, Lin Xi

doi:10.1111/1440-1681.12563

Cited by 44 publications

(42 citation statements)

References 47 publications

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“…Apelin expression in tumors is regulated by hypoxia [181] and is suggested to promote tumor growth in several ways. Apelin directly stimulates tumor cell proliferation [181][182][183], tumor cell migration and metastasis [184,185]. Apelin also stimulates neoangiogenesis and microvascular proliferation within the tumor, leading to enhanced tumor growth [174,176,186,187].…”

Section: Apelin/aplnr Pathwaymentioning

confidence: 99%

Tumor angiogenesis: causes, consequences, challenges and opportunities

Lugano

Ramachandran

Dimberg

2019

Cell. Mol. Life Sci.

1,157

834

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Tumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur simultaneously within the same cancer tissue. These processes are orchestrated by a range of secreted factors and signaling pathways and can involve participation of non-endothelial cells, such as progenitors or cancer stem cells. Anti-angiogenic therapies using either antibodies or tyrosine kinase inhibitors have been approved to treat several types of cancer. However, the benefit of treatment has so far been modest, some patients not responding at all and others acquiring resistance. It is becoming increasingly clear that blocking tumors from accessing the circulation is not an easy task to accomplish. Tumor vessel functionality and gene expression often differ vastly when comparing different cancer subtypes, and vessel phenotype can be markedly heterogeneous within a single tumor. Here, we summarize the current understanding of cellular and molecular mechanisms involved in tumor angiogenesis and discuss challenges and opportunities associated with vascular targeting.

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Section: Apelin/aplnr Pathwaymentioning

confidence: 99%

Tumor angiogenesis: causes, consequences, challenges and opportunities

Lugano

Ramachandran

Dimberg

2019

Cell. Mol. Life Sci.

1,157

834

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“…In the cardiovascular system, apelin/APJ can reduce blood pressure, promote the formation of new blood vessels, and reduce arterial tension and the heart preload (Yu et al, ). In addition, apelin/APJ can regulate GI function and insulin sensitivity, promote cell proliferation and migration, induce angiogenesis, maintain cardiovascular homeostasis, regulate immune function, and even protect retinal neuronal cells (Adam et al, ; Castan‐Laurell et al, ; Chun et al, ; Ishimaru et al, ; Kostopoulos, Spiroglou, Varakis, Apostolakis, & Papadaki, ; D. Lv et al, ; Tiani et al, ; G. Wang et al, ; Q. Zhou, Cao, & Chen, ). Much research has shown that apelin may play a role in body fluid homeostasis, including water and food consumption, as well as energy metabolism (Cao, Li, & Chen, ; L. Guo et al, ; Najafipour, Soltani Hekmat, Nekooian, & Esmaeili‐Mahani, ; Taheri et al, ).…”

Section: Introductionmentioning

confidence: 99%

Function and regulation of apelin/APJ system in digestive physiology and pathology

Huang

Luo

Liu

et al. 2018

Journal Cellular Physiology

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Apelin is an endogenous ligand of seven‐transmembrane G‐protein‐coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, liver, kidney, and gastrointestinal tract and even in tumor tissues. Studies show that apelin messenger RNA is widely expressed in gastrointestinal (GI) tissues, including stomach and small intestine, which is closely correlated with GI function. Thus, the apelin/APJ system may exert a broad range of activities in the digestive system. In this paper, we review the role of the apelin/APJ system in the digestive system in physiological conditions, such as gastric acid secretion, control of appetite and food intake, cell proliferation, cholecystokinin secretion and histamine release, gut–brain axis, GI motility, and others. In pathological conditions, the apelin/APJ system plays an important role in the healing process of stress gastric injury, the clinical features and prognosis of patients with gastric cancers, the reduction of inflammatory response to enteritis and pancreatitis, the mediation of liver fibrogenesis, the promotion of liver damage, the inhibition of liver regeneration, the contribution of splanchnic neovascularization in portal hypertension, the treatment of colon cancer, and GI oxidative damage. Overall, the apelin/APJ system plays diversified functions and regulatory roles in digestive physiology and pathology. Further exploration of the relationship between the apelin/APJ system and the digestive system will help to find new and effective drugs for treating and alleviating the pain of digestive diseases.

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“…In the cardiovascular system, apelin/APJ system can reduce blood pressure, promote the formation of new blood vessels, reduce arterial tension, and the heart preload (Yu et al, ). In addition, apelin/APJ system can regulate gastrointestinal function and insulin sensitivity, promote cell proliferation and migration, induce angiogenesis, and regulate immune function (Adam et al, ; Castan‐Laurell et al, ; Lv et al, ; Tiani et al, ; Wang et al, ; Zhou, Cao, & Chen, ). Various researches show that apelin may play a role in body fluid homeostasis (Najafipour, Soltani Hekmat, Nekooian, & Esmaeili‐Mahani, ).…”

Section: Introductionmentioning

confidence: 99%

Apelin/APJ system: A novel potential therapy target for kidney disease

Huang

Chen

2017

Journal Cellular Physiology

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Apelin is an endogenous ligand of seven-transmembrane G protein-coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, kidney, and even in tumor tissues. Studies show that apelin mRNA is highly expressed in the inner stripe of kidney outer medulla, which plays an important role in process of water and sodium balance. Additionally, more studies also indicate that apelin/APJ system exerts a broad range of activities in kidney. Therefore, we review the role of apelin/APJ system in kidney diseases such as renal fibrosis, renal ischemia/reperfusion injury, diabetic nephropathy, polycystic kidney disease, and hemodialysis (HD). Apelin/APJ system can improve renal interstitial fibrosis by reducing the deposition of extracellular matrix. Apelin/APJ system significantly reduces renal ischemia/reperfusion injury by inhibiting renal cell death. Apelin/APJ system involves the progression of diabetic nephropathy (DN). Apelin/APJ system also predicts the process of polycystic kidney disease. Besides, apelin/APJ system prevents some dialysis complications in HD patients. And apelin/APJ system alleviates chronic kidney disease (CKD) by inhibiting vascular calcification (VC). Overall, apelin/APJ system plays diversified roles in kidney disease and may be a potential target for the treatment of kidney disease.

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PAK1‐cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin‐13

Cited by 44 publications

References 47 publications

Tumor angiogenesis: causes, consequences, challenges and opportunities

Tumor angiogenesis: causes, consequences, challenges and opportunities

Function and regulation of apelin/APJ system in digestive physiology and pathology

Apelin/APJ system: A novel potential therapy target for kidney disease

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