LncRNA FRMD6‐AS1/miR‐491‐5p/USP13 pathway attenuated ferroptosis and contributed to liver fibrosis
Ziqiang Li,
Weilong Zou,
Xiangren Jin
et al.
Abstract:Liver fibrosis is an invertible pathophysiologic process featured by excessive accumulation of extracellular matrix (ECM) which injures liver cells and activates hepatic stellate cells (HSCs). Besides, inducing ferroptosis in activated HSCs can alleviate liver fibrosis. LncRNAs modulate ferroptosis in activated HSCs and ECM deposition in liver fibrosis. However, the role of lncRNA FRMD6‐AS1 in liver fibrosis is not discovered. In this study, lncRNA FRMD6‐AS1 was dramatically up‐regulated in activated HSCs. Kno… Show more
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