HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis
Gülseren Özduman,
Faruk Şimşek,
Aadil Javed
et al.
Abstract:Hematological and neurological expressed 1 (HN1) is homolog of Jupiter protein from Drosophila melanogaster where it functions as a microtubule‐associated protein. However, in mammalian cells, HN1 is associated partially with y‐tubulin in centrosomes, Stathmin for stabilizing microtubules, and Cdh1 for regulating Cyclin B1 for cell cycle regulation. Moreover, HN1 overexpression leads to early mitotic exit as well. Other molecular functions and interactions of HN1 are not clear yet. Here, based on our previous … Show more
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