2021
DOI: 10.1111/tan.14505
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Abstract: The HLA system plays a pivotal role both in transplantation and immunology. While classical HLA genotypes matching is made at the allelic level, recent progresses were developed to explore antibody-antigen recognition by studying epitopes. Donor to recipient matching at the epitopic level is becoming a trending topic in the transplantation research field because anti-HLA antibodies are epitope-specific rather than allele-specific. Indeed, different HLA alleles often share common epitopes. We present the HLA-Ep… Show more

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Cited by 2 publications
(1 citation statement)
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“…Building on those, new bioinformatic tools are being developed, for example, HLA-Epi. 42 New terms are introduced, for example, “epitope typing,” 43 “antibody-binding eplets‚” or “epitypes.” 39 The use of such tools and the associated evocative terminology continues to build on precarious infrastructure and supports a false sense of familiarity and confidence. The use of a computer program, as well as terms that sound sophisticated and advanced, may help promote and market tools that have poor scientific basis.…”
Section: Assumptions Made In Data Interpretation To Support the Use O...mentioning
confidence: 99%
“…Building on those, new bioinformatic tools are being developed, for example, HLA-Epi. 42 New terms are introduced, for example, “epitope typing,” 43 “antibody-binding eplets‚” or “epitypes.” 39 The use of such tools and the associated evocative terminology continues to build on precarious infrastructure and supports a false sense of familiarity and confidence. The use of a computer program, as well as terms that sound sophisticated and advanced, may help promote and market tools that have poor scientific basis.…”
Section: Assumptions Made In Data Interpretation To Support the Use O...mentioning
confidence: 99%