<scp>CD</scp>93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous <scp>DNA</scp>

Nativel, Brice; Ramin‐Mangata, Stéphane; Mevizou, Rudy; Figuester, Audrey; Andries, Jessica; Iwema, Thomas; Ikewaki, Nobunao; Gasque, Philippe; Viranaïcken, Wildriss

doi:10.1111/imm.13100

Cited by 26 publications

(24 citation statements)

References 29 publications

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“…CD93 is a transmembrane glycoprotein that is expressed primarily in endothelial cells but also in granulocytes, monocytes, platelets and stem cells [66]. The protein is involved in several processes of innate immunity, such as adhesion, phagocytosis and inflammation [67]. In the context of the latter, CD93 may act as a plasma membrane receptor for DNA for delivery to endosomal TLR9.…”

Section: Discussionmentioning

confidence: 99%

Key Vitamin D Target Genes with Functions in the Immune System

2020

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The biologically active form of vitamin D 3 , 1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), modulates innate and adaptive immunity via genes regulated by the transcription factor vitamin D receptor (VDR). In order to identify the key vitamin D target genes involved in these processes, transcriptome-wide datasets were compared, which were obtained from a human monocytic cell line (THP-1) and peripheral blood mononuclear cells (PBMCs) treated in vitro by 1,25(OH) 2 D 3 , filtered using different approaches, as well as from PBMCs of individuals supplemented with a vitamin D 3 bolus. The led to the genes ACVRL1, CAMP, CD14, CD93, CEBPB, FN1, MAPK13, NINJ1, LILRB4, LRRC25, SEMA6B, SRGN, THBD, THEMIS2 and TREM1. Public epigenome-and transcriptome-wide data from THP-1 cells were used to characterize these genes based on the level of their VDR-driven enhancers as well as the level of the dynamics of their mRNA production. Both types of datasets allowed the categorization of the vitamin D target genes into three groups according to their role in (i) acute response to infection, (ii) infection in general and (iii) autoimmunity. In conclusion, 15 genes were identified as major mediators of the action of vitamin D in innate and adaptive immunity and their individual functions are explained based on different gene regulatory scenarios.

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Section: Discussionmentioning

confidence: 99%

Key Vitamin D Target Genes with Functions in the Immune System

2020

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“…Another peculiarity of porcine pDC was found to be shared between blood and lymphoid tissue: the high expression of complement-related genes such as C2, C3 , or CD93 . Interestingly, CD93 was shown to be involved in delivery of CpG ODN to endosomal TLR9 ( 49 ) and could be an interesting way of targeting and activating porcine pDC. Both porcine cDC subsets from lymphoid tissues also showed expression of markers that were not expressed on their blood counterparts.…”

Section: Discussionmentioning

confidence: 99%

High-Resolution Profiling of Innate Immune Responses by Porcine Dendritic Cell Subsets in vitro and in vivo

et al. 2020

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The present study investigated the transcriptomic response of porcine dendritic cells (DC) to innate stimulation in vitro and in vivo . The aim was to identify DC subset-specialization, suitable Toll-like receptor (TLR) ligands targeting plasmacytoid DC (pDC), and the DC activation profile during highly and low virulent classical swine fever virus (CSFV, strain Eystrup and Pinar del Rio, respectively) infection, chosen as model for a virus causing a severe immunopathology. After identification of porcine conventional DC (cDC) 1, cDC2, pDC and a monocyte-derived subset in lymphoid tissues, we characterized DC activation using transcriptomics, and focused on chemokines, interferons, cytokines, as well as on co-stimulatory and inhibitory molecules. We demonstrate that porcine pDC provide important signals for Th1 and interferon responses, with CpG triggering the strongest responses in pDC. DC isolated early after infection of pigs with either of the two CSFV strains showed prominent upregulation of CCL5, CXCL9, CXCL10, CXCL11 , and XCL1 , as well as of the cytokines TNFSF13B, IL6, IL7, IL12B, IL15, IL27 . Transcription of IL12B and many interferon genes were mostly restricted to pDC. Interestingly, the infection was associated with a prominent induction of inhibitory and cell death receptors. When comparing low and highly virulent CSFV strains, the latter induced a stronger inflammatory and antiviral response but a weaker cell cycle response, and reduced antigen presentation functions of DC. Taken together, we provide high-resolution information on DC activation in pigs, as well as information on how DC modulation could be linked to CSFV immunopathology.

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“…Although McGreal et al [ 7 ] have shown that the protein does not bind C1q in physiological state, novel studies have confirmed the association of CD93 with phagocytosis of apoptotic cells [ 8 , 9 ]. In addition, CD93 has been shown to be involved in angiogenesis, endothelial cell adhesion, and inflammatory response [ 4 , 5 , 10 , 11 ]. Increased expression of membrane CD93 was observed on activated macrophages along with increased concentrations of sCD93 in plasma [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

et al. 2021

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Cluster of differentiation 93 (CD93), also known as complement component 1q receptor 1 is a transmembrane glycoprotein expressed in endothelial and hematopoietic cells and associated with phagocytosis, cell adhesion, angiogenesis and inflammation. The extracellular part, soluble CD93 (sCD93), is released to body fluids in inflammation. Data on sCD93 in kidney diseases are limited. Our aim was to evaluate serum sCD93 in long-term kidney transplant recipients as a marker of inflammation and endothelial dysfunction that may be potentially useful in early recognition of graft dysfunction. Seventy-eight adult patients with functioning kidney graft and stable clinical state were examined at least one year after kidney transplantation. Serum sCD93 was measured by enzyme immunosorbent assay. Estimated glomerular filtration rate (eGFR) and albuminuria or proteinuria were assessed at baseline and over one-year follow-up. Increased sCD93 was associated with lower baseline eGFR independently of the confounders. Moreover, sCD93 was negatively associated with eGFR during one-year follow-up in simple analysis; however, this was not confirmed after adjustment for confounders. Baseline sCD93 was positively associated with baseline albuminuria and with increased proteinuria during the follow-up. Serum sCD93 was not correlated with other studied inflammatory markers (interleukin 6, C-reactive protein, procalcitonin and C3 and C4 complement components). To the best of our knowledge, this is the first report regarding the concentrations of sCD93 in kidney transplant recipients and one of the first reports showing the inverse association between sCD93 and renal function. Serum sCD93 should be further evaluated as a diagnostic and prognostic marker in renal transplantation.

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CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA

Cited by 26 publications

References 29 publications

Key Vitamin D Target Genes with Functions in the Immune System

Key Vitamin D Target Genes with Functions in the Immune System

High-Resolution Profiling of Innate Immune Responses by Porcine Dendritic Cell Subsets in vitro and in vivo

Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

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