2018
DOI: 10.15252/embr.201845856
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Abstract: Interventions that promote healthy aging are typically associated with increased stress resistance. Paradoxically, reducing the activity of core biological processes such as mitochondrial or insulin metabolism promotes the expression of adaptive responses, which in turn increase animal longevity and resistance to stress. In this study, we investigated the relation between the extended Caenorhabditis elegans lifespan elicited by reduction in mitochondrial functionality and resistance to genotoxic stress. We fin… Show more

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Cited by 8 publications
(5 citation statements)
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“…Instead, the different bacteria neither affected the fertility in basal condition ( Supplementary Figure 3E ) nor the increased sensitivity to UVB ( Supplementary Figure 3F , 3G ) of the ahr-1 mutant. This is consistent with our previous findings showing germline sensitivity to UVB-induced apoptosis does not correlate with lifespan outcomes [ 36 ]. The lipid droplet content, which did not change between wild-type and ahr-1 mutants, was however similarly affected by the different bacteria ( not shown ).…”
Section: Resultssupporting
confidence: 94%
See 1 more Smart Citation
“…Instead, the different bacteria neither affected the fertility in basal condition ( Supplementary Figure 3E ) nor the increased sensitivity to UVB ( Supplementary Figure 3F , 3G ) of the ahr-1 mutant. This is consistent with our previous findings showing germline sensitivity to UVB-induced apoptosis does not correlate with lifespan outcomes [ 36 ]. The lipid droplet content, which did not change between wild-type and ahr-1 mutants, was however similarly affected by the different bacteria ( not shown ).…”
Section: Resultssupporting
confidence: 94%
“…In mammals, UVB radiations activate AHR-1 through the formation of 6-formylindolo[3,2-b]carbazole (FICZ) [ 20 , 21 ]. In C. elegans UVB radiation shortens lifespan, induces embryonic lethality and germline cells apoptosis in a dose-dependent manner [ 35 , 36 ]. We showed that ahr-1(ju145) is more sensitive to UVB-induced embryonic lethality ( Figure 1H ).…”
Section: Resultsmentioning
confidence: 99%
“…Survival analyses were carried out with the standard procedure in the field as routinely carried out in our laboratory ( Torgovnick et al, 2018 ). Briefly, a synchronized population of 60–80 worms was used to start the lifespan analysis.…”
Section: Methodsmentioning
confidence: 99%
“…The atm-1(gk186) ; atl-1(tm853) suppressor screen was undertaken using a bacterial feeding RNAi targeting 201 DDR-related genes [ 43 ]. A protocol describing our screening method, including quantitation of the RNAi effect-size and significance testing, is provided in File S1 and Tables S1–S3 .…”
Section: Methodsmentioning
confidence: 99%