2023
DOI: 10.15252/emmm.202317450
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle‐stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown. Many clinical studies have shown that POI patients are generally underweight, indicating a potential correlation between POI and metabolic disorders. To understand the pathogenesis of POI, we performed metabolomics analysis on serum and identified branch‐chain amino … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

2
0
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 10 publications
(2 citation statements)
references
References 70 publications
2
0
0
Order By: Relevance
“…Additionally, metabolic disorders such as insulin resistance, obesity, and altered lipid metabolism have also been shown to affect ovarian function. Serum branched‐chain amino acid insufficiency‐related metabolic disorders have been identified in two Chinese POI cohorts 33 . In the present study, we also found significant changes in mitochondrial metabolism, aging‐related molecules and pathways in the ovaries of Tufm KI/KI female mice through untargeted metabonomics.…”
Section: Discussionsupporting
confidence: 73%
See 1 more Smart Citation
“…Additionally, metabolic disorders such as insulin resistance, obesity, and altered lipid metabolism have also been shown to affect ovarian function. Serum branched‐chain amino acid insufficiency‐related metabolic disorders have been identified in two Chinese POI cohorts 33 . In the present study, we also found significant changes in mitochondrial metabolism, aging‐related molecules and pathways in the ovaries of Tufm KI/KI female mice through untargeted metabonomics.…”
Section: Discussionsupporting
confidence: 73%
“…Serum branched-chain amino acid insufficiency-related metabolic disorders have been identified in two Chinese POI cohorts. 33 In the present study, we also found significant changes in mitochondrial metabolism, aging-related molecules and pathways in the ovaries of Tufm KI/KI female mice through untargeted metabonomics. These metabolic disturbances may contribute to the development of mitochondrial dysfunction, further exacerbating ovarian aging.…”
Section: Discussionsupporting
confidence: 72%