Psychosocial rehabilitation services for persons with substance use disorder at Centre for Addiction Medicine is an integral part of the services provided by the Department of Psychiatry, National Institute of Mental Health and Neurosciences (Institute of National Importance), a premier mental health institute in Asia known for its multi-disciplinary approach to clinical service, training and research. This article provides an account of psychosocial rehabilitation services for persons with substance use disorders at the centre for addiction medicine.