2020
DOI: 10.1002/jat.3976
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Abstract: Cancer remains one of the deadliest non‐infectious diseases of the 21st century, causing millions of mortalities per year worldwide. Analyses of conventional treatments, such as radiotherapy and chemotherapy, have shown not only a lower therapeutic efficiency rate but also plethora of side‐effects. Considering the desperate need to identify promising anticancer agents, researchers are in quest to design and develop new tumoricidal drugs from natural sources. Over the past few years, scorpion venoms have shown … Show more

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Cited by 8 publications
(3 citation statements)
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“…Kv1.3(KCNA3), a critical isoform in the Kv family, is selectively permeable to potassium ions and is activated upon changes in membrane potential ( 14 ). Overexpression of Kv1.3 channels has been observed in the breast, colon, smooth muscle, skeletal muscle, lymph node, and CLL.…”
Section: Relationship Between Potassium Channel and Tumormentioning
confidence: 99%
“…Kv1.3(KCNA3), a critical isoform in the Kv family, is selectively permeable to potassium ions and is activated upon changes in membrane potential ( 14 ). Overexpression of Kv1.3 channels has been observed in the breast, colon, smooth muscle, skeletal muscle, lymph node, and CLL.…”
Section: Relationship Between Potassium Channel and Tumormentioning
confidence: 99%
“…Scorpions are among the most primitive arthropods of the animal kingdom that have existed on the earth for more than 400 million years and are globally distributed. Since ancient times, scorpion venom has been used in traditional medicinal applications of different countries, especially in China, India, Cuba, Africa, and Spain 85 . Scorpion venom is a complicated mixture of proteins (peptides and enzymes) and non‐proteins (nucleotides, lipids, free amino acids, inorganic salts, and water) 86 .…”
Section: Antineoplastic Drugs Classified By Sourcementioning
confidence: 99%
“…Cancer is one of the deadliest diseases in the 21st century. 1 It is characterized by high morbidity, high mortality, high treatment costs, and great difficulty in curing. 2 It has become a global public health burden.…”
Section: Introductionmentioning
confidence: 99%