Sclerosing dermatoses

Young, Edward M.; Barr, Ronald J.

doi:10.1111/j.1600-0560.1985.tb00440.x

Cited by 31 publications

(4 citation statements)

References 35 publications

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“…Since the literature also records cases of hypodermatitis sclerodermiformis due to various drugs (vi tamin K, pentazocina, bleomycin and other foreign substance injections) [6], it cannot be excluded that the drug was not at least partially responsible, together with the trauma, for the lesion in our patient, although we feel that this is unlikely.…”

Section: Isomorphic Phenomenon In Morpheamentioning

confidence: 63%

Isomorphic Phenomenon in Morphea

Tosti

Manuzzi

Bardazzi³

1988

Dermatology

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Section: Isomorphic Phenomenon In Morpheamentioning

confidence: 63%

Isomorphic Phenomenon in Morphea

Tosti

Manuzzi

Bardazzi³

1988

Dermatology

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“…The etiology of scleroderma (localized scleroderma and systemic scleroderma) is not known. It was thought to be an autoimmune disease and a disease of the vascular walls (7) . Antibodies to type IV collagen has been demonstrated in scleroderma (8) .…”

Section: Discussionmentioning

confidence: 99%

Localized scleroderma in a woman irradiated at two sites for endometrial and breast carcinoma: A case history and a review of the literature

Ullén¹,

Björkholm²

2003

Int J Gynecol Cancer

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Localized scleroderma is an uncommon side-effect of radiotherapy. We report a unique case with multiple asynchronous primary malignant tumors, which developed localized scleroderma after radiotherapy. A 67-year-old healthy woman received external irradiation for endometrial cancer. Three years later she underwent partial mastectomy and postoperative radiotherapy because of breast cancer. A progressive fibrosis developed in the breast. Within 12 months similar skin reactions were also seen in the irradiated abdominal wall and on both lower extremities. Biopsies revealed scleroderma lesions of breast and abdominal wall and scleroderma-like lesions on the legs. The lesions dissolved partially without generalization. This case, in contrast to most of the cases previously reported in the literature, illustrates not only lesions outside of radiation ports, but also that radiotherapy given to one cancer site can affect distant skin at a previously irradiated cancer site. When a localized scleroderma is diagnosed, further curative radiotherapy should be cautiously prescribed irrespective of cancer site.

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“…Sclerosing dermatoses (SD) are a heterogeneous group of diseases characterized by alterations in collagen and/or fibroblasts. 1 Morphoea, systemic sclerosis (SS) and chronic graft-versus-host disease (cGvHD) are among the most common types of SD. Monitoring the disease activity of SD and clinical decision-making are often challenging.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of high‐frequency ultrasonography in the evaluation and monitoring of sclerosing dermatoses: a cohort study

Marti‐Marti

Morgado‐Carrasco

Podlipnik

et al. 2021

Clin Experimental Derm

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Background. Monitoring of disease activity in sclerosing dermatoses (SD) can be challenging and tools to support clinical decision-making are lacking. Aim. To analyse the impact of high-frequency ultrasonography (HFUS) on the clinical management of SD and to describe the US characteristics of disease activity. Methods. This was a cohort study of patients with various SD [morphoea, systemic sclerosis (SS) and chronic graft-versus-host disease (cGvHD)] who underwent HFUS between January 2017 and August 2019. HFUS criteria for diagnosing active SD were increased Doppler vascularity and/or meeting all B-mode greyscale US signs of activity. Discordance in SD activity between HFUS and clinical examination was evaluated at the time of the first US assessment. Changes in patient management were instituted after HFUS were recorded. Results. In total, 72 patients (31 with morphoea, 19 with SS and 22 with cGvHD), who underwent 163 HFUS sessions in total, were included. All HFUS-active morphoea lesions exhibited increased vascularity, and all HFUS-active SS exhibited dermal thickening and dermal hypoechogenicity. HFUS-active cGvHD displayed increased dermal thickness and loss of definition of the dermal-hypodermal junction, and there were signs of panniculitis in 80% of cases and of increased vascularity in 70%. Discordance in disease activity between clinical and HFUS evaluation was found in 17 (23.6%) patients. Changes in clinical management after HFUS were made for 14 (19.4%) patients: treatment discontinuation for 6 patients (42.9%), treatment initiation for 5 (35.7%), medication change for 2 (14.3%) and skin biopsy taken for 1 (7.1%). Conclusion. HFUS seems an efficacious support tool in the monitoring of SD activity with a notable impact on clinical management. Further studies are warranted to evaluate the impact of HFUS-supported management changes on SD outcomes.

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Sclerosing dermatoses

Abstract: The sclerosing dermatoses include a variety of conditions characterized clinically by firm, hard skin and histologically by alterations in collagen and/or fibroblasts.

Cited by 31 publications

References 35 publications

Isomorphic Phenomenon in Morphea

Isomorphic Phenomenon in Morphea

Localized scleroderma in a woman irradiated at two sites for endometrial and breast carcinoma: A case history and a review of the literature

Usefulness of high‐frequency ultrasonography in the evaluation and monitoring of sclerosing dermatoses: a cohort study

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