Scleromyxedema

Abstract

An unusual, nodulocystic form of scleromyxedema (lichen myxedematosus) developed in a 48-year-old man with a six-year history of psoriasis. The scleromyxedema responded to intermittent therapy with melphalan and prednisone. Dermabrasion smoothed and softened the skin and increased the mobility of the perioral skin. Two months after remission of the skin lesions, psoriasis recurred.

Scleromyxedema with Subcutaneous Nodules: Successful Treatment with Thalidomide and Intravenous Immunoglobulin

“…An unusual nodulocystic form on the face was successfully treated with melphalan [27]. An extensive nodular variant on the face regressed after radiation therapy [16].…”

Cutaneous manifestations of paraproteinaemia. Part II

“…Review bone marrow examination is more often normal. Myeloma was recorded by Perry, Montgomery & Stickney (i960) but this was not confirmed on follow-up (Wright et al, 1976). Jablonska & Stachow (1972) reported a patient with IgG kappa myeloma and diffuse 'sclerodermatous' skin involvement who presumably had scleromyxoedema, although this possibility was not considered by the authors.…”

“…Certain authors have suggested that the paraprotein should be considered as essential for the diagnosis (Hill, Crawford & Rogers, 1976) but there are several reports of clinically typical cases were no paraprotein has been detected (Rudner, Mehregan & Pinkus, 1966;Rowell, Waite & Scott, 1969;Tay & Khoo, 1970;Howsden, Herndon & Freeman, 1975;Jessen, Straight & Becker, 1978). Some cases have responded favourably to cytotoxic therapy (Feldman et al, 1969, Wright et al, 1976, which suggests that the paraprotein is of some aetiological importance, but the cases that responded were not always the ones with associated gammopathies (Howsden et al, 1975;Jessen et al, 1978). One case of lichen myxoedematosus showed spontaneous resolution despite the persistence of the paraprotein (Hardie et al, 1979).…”