1983
DOI: 10.1001/archderm.119.12.957
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Scleroderma. A model for fibrosis

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Cited by 20 publications
(10 citation statements)
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“…However, inadequate collagen production can lead to fibrosis and severe impairment of organ function. Systemic sclerosis (SSc)' is a disease characterized by excessive deposition of connective tissue proteins (1). In the initial stages of SSc a perivascular mononuclear cell infiltrate is found in the dermis and other involved organs and is associated with increased collagen synthesis in the surrounding fibroblasts (2)(3)(4).…”
Section: Introductionmentioning
confidence: 99%
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“…However, inadequate collagen production can lead to fibrosis and severe impairment of organ function. Systemic sclerosis (SSc)' is a disease characterized by excessive deposition of connective tissue proteins (1). In the initial stages of SSc a perivascular mononuclear cell infiltrate is found in the dermis and other involved organs and is associated with increased collagen synthesis in the surrounding fibroblasts (2)(3)(4).…”
Section: Introductionmentioning
confidence: 99%
“…Growth factors released from inflammatory cells have long been implicated in the pathogenesis of fibrosis (1,(3)(4)(5)(6). Due to the recent availability ofpurified preparations oflymphokines, a clear picture has emerged as to how these components can influence collagen synthesis in cultured fibroblasts.…”
Section: Introductionmentioning
confidence: 99%
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“…The amount ofcollagen in tissues is maintained by control of the balance between synthesis and degradation of collagen and is transiently altered in repair processes such as wound healing (1). Abnormalities in collagen turnover may lead to pathological fibrosis ofthe skin in diseases such as scleroderma (2), keloid formation (3,4), or pathological fibrosis of internal organs such as the liver or lungs. Studies from several laboratories have demonstrated that products of inflammatory cells may function in the regulation of collagen synthesis and degradation (5), particularly in cell culture systems (6)(7)(8)(9)(10)(11)(12)(13).…”
Section: Introductionmentioning
confidence: 99%
“…An increased IL-2 production by peripheral lymphocytes [ 12], production by Tccllsof a lymphokinc that stimulates fibroblast collagen synthesis [13], increases in scrum IL-2 levels, which correlated with disease progression and skin involvement [14], as well as an abnormal increase in the helper/suppressor ratio [ 15] are some of them. Much less is known about the immunological status of patients with reactive scleroderma.…”
Section: Discussionmentioning
confidence: 99%