Scleral Hydraulic Conductivity and Macromolecular Diffusion in Patients with Uveal Effusion Syndrome

Jackson, Timothy L.; Hussain, Abir; Morley, Ana M. S.; Sullivan, Paul; Hodgetts, A; El-Osta, Austen; Hillenkamp, Jost; Charles, Stephen; Sheard, Richard; Williamson, Tom H.; Kumar, Arun; Laidlaw, D A H; Woon, W H; Costen, Mark J.; Luff, A J; Marshall, John

doi:10.1167/iovs.08-1980

Cited by 43 publications

(41 citation statements)

References 15 publications

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“…Indeed, ciliochoroidal effusion can be the consequence of various inflammatory and hydrostatic ocular conditions. In eyes affected by idiopathic UES, a primary abnormality of the sclera may play a causal role in the dysfunction of choroidal fluid dynamics [12]. Histochemical studies have shown an accumulation of glycosaminoglycan-like deposits filling the interfibrillar spaces in sclera excised from eyes affected by UES [13][14][15][16].These alterations are associated with the abnormal transscleral diffusion of choroidal extravascular proteins and the accumulation of fluid in the choroid as a result of increased osmolarity.…”

Section: Discussionmentioning

confidence: 99%

Uveal effusion syndrome mimicking severe chronic posterior uveitis: a case series of seven eyes of four patients

Maggio

Polito

Prigione

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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UES may be mistaken for other sources of ciliochoroidal effusion. Early diagnosis and treatment is critical to avoid unnecessary procedures and to prevent severe visual loss as a result of neuroretinal damage. Surgical treatment based on the extent and characteristics of the disease may be effective for the resolution of ciliochoroidal effusion, even in type 3 UES, where conventional surgery has proved unsuccessful.

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Section: Discussionmentioning

confidence: 99%

Uveal effusion syndrome mimicking severe chronic posterior uveitis: a case series of seven eyes of four patients

Maggio

Polito

Prigione

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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“…MFRP mutations may also cause retinitis pigmentosa or foveoschisis [5] and it is possible that a malfunction of the gene itself may contribute to UES. Indeed, a recent laboratory study of specimens excised from nanophthalmos patients with UES found the scleral hydraulic conductance to be in the normal range [6].…”

Section: Introductionmentioning

confidence: 99%

Scleral punch method with topical mitomycin c for safe revision of failed deep sclerectomy in nanophthalmic uveal effusion syndrome

Sabrosa

Smith

MacLaren

2009

Graefes Arch Clin Exp Ophthalmol

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“…[5][6][7] Medical treatment using NSAIDs has been described with rare success. 8 PAs are known to enhance scleral macromolecular permeability.…”

Section: Discussionmentioning

confidence: 99%

Medical therapy for uveal effusion syndrome

Derk¹,

Benčić²,

Ćorluka

et al. 2014

Eye

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Purpose To report a case series of three patients with bilateral uveal effusion syndrome (UES), treated conservatively with oral carbonic anhydrase inhibitors and topical prostaglandin analogues (PAs). Methods Three patients with bilateral UES were treated with the same initial therapy. Topical PA latanoprost 0.005% and acetazolamide 250 mg were administered in order to reduce intraocular pressure, improve uveoscleral outflow, and facilitate resolution of uveal effusion. Results The chorioretinal detachment resolved within 3 months in two reported patients while the third one underwent surgery on his left eye. After clinical improvement, further oral therapy with acetazolamide was stopped, while topical prostaglandins were continued for at least the next 3 months. All patients were free from recurrence during the follow-up period. Conclusion Although the usually recommended UES therapy is partial or full-thickness sclerectomy, our case series showed apparent resolution of chorioretinal detachment in two patients on medical therapy alone. Conservative therapy may be the first step before the standard recommended surgical approach, but further studies are needed to verify the effectiveness of reported therapy.

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Scleral Hydraulic Conductivity and Macromolecular Diffusion in Patients with Uveal Effusion Syndrome

Abstract: UES is not caused by reduced scleral hydraulic conductivity, which tends to be higher than expected. Reduced macromolecular diffusion may impede the normal transscleral egress of albumin with subsequent osmotic fluid retention in some, but not all eyes.

Cited by 43 publications

References 15 publications

Uveal effusion syndrome mimicking severe chronic posterior uveitis: a case series of seven eyes of four patients

Uveal effusion syndrome mimicking severe chronic posterior uveitis: a case series of seven eyes of four patients

Scleral punch method with topical mitomycin c for safe revision of failed deep sclerectomy in nanophthalmic uveal effusion syndrome

Medical therapy for uveal effusion syndrome

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