JAMA
 2006
DOI: 10.1001/jama.296.13.1573
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Scientists Study Fat as Endocrine Organ

Tracy Hampton1
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Cited by 15 publications

(7 citation statements)
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“…What could possibly account for the negative impact of obesity on burnout? There is growing evidence that fat cells or adipocytes represent dynamic entities that generate signals throughout the body, representing an endocrine organ in its own right, and that this endocrine organ is associated with a chronic inflammatory state invoking the production of cytokines among obese persons (Hampton, 2006). Therefore, adiposity is closely related to the production of cytokines, which in turn are closely interrelated with neurotransmitters known to be responsible for changes in affective states (Maier & Watkins, 1998).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…What could possibly account for the negative impact of obesity on burnout? There is growing evidence that fat cells or adipocytes represent dynamic entities that generate signals throughout the body, representing an endocrine organ in its own right, and that this endocrine organ is associated with a chronic inflammatory state invoking the production of cytokines among obese persons (Hampton, 2006). Therefore, adiposity is closely related to the production of cytokines, which in turn are closely interrelated with neurotransmitters known to be responsible for changes in affective states (Maier & Watkins, 1998).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Adipokines that may be important to obesity-related morbidity include leptin, tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), free fatty acids, and adiponectin [8][9][10] . Abnormalities in adipokines may cause inflammation and abnormal cell signalling which in turn lead to impaired cellular metabolism and function.…”
Section: Adipokinesmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It is now recognized that adipose tissue function is regulated by endocrine system and that it behaves as an endocrine organ producing hormones. Therefore, inappropriate deposits of fat could be derived from interference in the hormonal control of adipose tissue functions and be themselves responsible for endocrine dysregulations [ 2 ].…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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