Scientists Probe Ways to Curb Opioid Abuse Without Hindering Pain Treatment

Kuehn, Bridget M.

doi:10.1001/jama.297.18.1965

JAMA

2007

DOI: 10.1001/jama.297.18.1965

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

Scientists Probe Ways to Curb Opioid Abuse Without Hindering Pain Treatment

Bridget M. Kuehn¹

Help me understand this report

Cited by 9 publications

(2 citation statements)

References 0 publications

Supporting

0

Mentioning

2

Contrasting

0

Unclassified

0

Order By: Relevance

“…Our findings and the policy issues surrounding non-disclosure of substance abuse diagnoses call for careful attention to assessment and screening [5], early detection, and development of more effective clinical management processes [12,13,27], as well as of efficacy studies for this population. The decline in trends for this group suggests that attention to screening and prescription practices may be increasing as concern grows about prescription drug abuse and other potential adverse effects of long-term opioid use.…”

Section: Discussionmentioning

confidence: 99%

Trends in prescribed opioid therapy for non-cancer pain for individuals with prior substance use disorders

Weisner

¹

,

Campbell

²

,

Ray

³

et al. 2009

Pain

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our findings and the policy issues surrounding non-disclosure of substance abuse diagnoses call for careful attention to assessment and screening [5], early detection, and development of more effective clinical management processes [12,13,27], as well as of efficacy studies for this population. The decline in trends for this group suggests that attention to screening and prescription practices may be increasing as concern grows about prescription drug abuse and other potential adverse effects of long-term opioid use.…”

Section: Discussionmentioning

confidence: 99%

Trends in prescribed opioid therapy for non-cancer pain for individuals with prior substance use disorders

Weisner

¹

,

Campbell

²

,

Ray

³

et al. 2009

Pain

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The therapeutic use and abuse of opioids has soared globally in recent years (Devi, 2011; Manchikanti and Singh, 2008; Kuehn, 2007a; b; 2009; Manchikanti, 2006). Between 1999 and 2002, the number of fatal opioid analgesic poisonings has increased by 91% while methadone-related deaths from 1999 to 2004 have increased by 390% (Paulozzi et al, 2006a; Paulozzi et al, 2006b).…”

Section: Introductionmentioning

confidence: 99%

Ligand interaction, binding site and G protein activation of the mu opioid receptor

Cui

¹

,

Yeliseev

²

,

Liu

³

2013

European Journal of Pharmacology

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Opioid analgesics and narcotic antagonists

Ghodse¹,

Galea²

2010

Side Effects of Drugs Annual

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA