Scientific Evaluation of Edible Fruits and Spices Used for the Treatment of Peptic Ulcer in Traditional Iranian Medicine

Abstract

In traditional Iranian medicine (TIM), several edible fruits and spices are thought to have protective and healing effects on peptic ulcer (PU). The present study was conducted to verify anti-PU activity of these remedies. For this purpose, edible fruits and spices proposed for the management of PU in TIM were collected from TIM sources, and they were searched in modern medical databases to find studies that confirmed their efficacy. Findings from modern investigations support the claims of TIM about the efficacy of many fruits and spices in PU. The fruit of Phyllanthus emblica as a beneficial remedy for PU in TIM has been demonstrated to have antioxidant, wound healing, angiogenic, anti-H. pylori, cytoprotective, antisecretory, and anti-inflammatory properties. The fruit of Vitis vinifera has been found to be anti-H. pylori, anti-inflammatory, wound healing, angiogenic, cytoprotective, and antioxidant. The fruit and aril of seed from Myristica fragrans exert their beneficial effects in PU by increasing prostaglandin, modulation of nitric oxide and inflammatory mediators, wound healing, antisecretory, antacid, antioxidant, and anti-H. pylori activities, and improving angiogenesis. Pharmacological and clinical studies for evaluation of efficacy of all TIM fruits and spices in PU and their possible mechanisms of action are recommended.

Preventive Care for Gastrointestinal Disorders; Role of Herbal Medicines in Traditional Persian Medicine

“…This kind of plants is a source of phenolic compounds and has dry and cold temperament (16). Antioxidant and anti-Helicobacter pylori properties of amla in animal model (mice) were shown in recent studies (17,18) although amla has multiple documented functions (Table 2) (19). These broad-range functions could vindicate the legitimacy of TPM believes about amla's influence on stomach.…”

Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna

“…Medicinal plants used in traditional and folk medicine of different areas may be valuable sources for discovering new drugs [107][108][109][110]. In ''Canon of Medicine'', a precious book written in 11 AD by the great Iranian physician Avicenna, variety of medicinal plants with different pharmacological activities has been introduced.…”

Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine

“…In traditional Iranian medicine, several edible fruits have been recommended for the management of peptic ulcers such as pumpkin and rice for their anti-acid and anti-oxidant activities (reviewed in [63]). The use of dwarf elder has been recommended as an anti-fungal remedy against mycotic skin infections [119] and as a painkiller to treat a variety of bone and joint pathologies [120].…”

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