Sciatic nerve regeneration by using collagen type I hydrogel containing naringin

Samadian, Hadi; Vaez, Ahmad; Ehterami, Arian; Salehi, Majid; Farzamfar, Saeed; Sahrapeyma, Hamed; Norouzi, Pirasteh

doi:10.1007/s10856-019-6309-8

Cited by 46 publications

(32 citation statements)

References 42 publications

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“…In turn, studies performed with animal models clearly indicated that flavonoid collagen grafts were more effective in regeneration of bone than a collagen matrix alone [373], have the potential to accelerate the formation of bone tissue in early healing stages [374], and exhibit anti-inflammatory activity by downregulating inflammatory-related genes [375]. Flavonoid-loaded collagen materials are also promising agents in the regeneration of cartilage [376] and nerves [377], as well as in dermal wound dressings [378]. Nature-derived active agents are especially attractive for the sake of medicinal benefits, as well as the reduction of scaffold costs.…”

Section: Conjugates Of Collagen/hap/flavonoids: Preparation and Applicationmentioning

confidence: 99%

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

et al. 2021

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Regenerative medicine is becoming a rapidly evolving technique in today’s biomedical progress scenario. Scientists around the world suggest the use of naturally synthesized biomaterials to repair and heal damaged cells. Hydroxyapatite (HAp) has the potential to replace drugs in biomedical engineering and regenerative drugs. HAp is easily biodegradable, biocompatible, and correlated with macromolecules, which facilitates their incorporation into inorganic materials. This review article provides extensive knowledge on HAp and collagen-containing compositions modified with drugs, bioactive components, metals, and selected nanoparticles. Such compositions consisting of HAp and collagen modified with various additives are used in a variety of biomedical applications such as bone tissue engineering, vascular transplantation, cartilage, and other implantable biomedical devices.

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Section: Conjugates Of Collagen/hap/flavonoids: Preparation and Applicationmentioning

confidence: 99%

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

et al. 2021

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“…The classical gravimetric method 11,38 was applied to measure the water uptake ability of the hydrogels. Each lyophilized specimen (n = 5) was weighed (m 0 ) and immersed into 20 ml phosphate-buffered saline (PBS) solution (pH = 7.4) at room temperature for 72 h. The samples were retrieved at appropriate intervals (1, 4, 8, … 72 h), the surface PBS solution removed using filter paper, and weighed again (m 1 ).…”

Section: In Vitro Swelling Kinetic Analysismentioning

confidence: 99%

“…The weight loss of the hydrogels was measured according to the classical gravimetric method. 11,38 Each lyophilized scaffold (n = 5) was weighed (W 0 ) and immersed into 20 mL PBS solution (pH = 7.4) at room temperature for 14 days. At days 7 and 14, samples were removed rinsed with DI water, frozen, lyophilized, and weighed again (W 1 ).…”

Section: Weight Loss Analysismentioning

confidence: 99%

Chitosan hydrogel loaded with Aloe vera gel and tetrasodium ethylenediaminetetraacetic acid (EDTA) as the wound healing material: in vitro and in vivo study

Salehi

Zamiri

Samadian

et al. 2020

J of Applied Polymer Sci

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The main aim of the current study was to develop a chitosan hydrogel containing Aloe vera gel and Ethylenediaminetetraacetic acid (EDTA) as the wound healing materials. Chitosan with the concentration of (2% w/v) was prepared in AA (0.5%, v/v) and Tetrasodium EDTA (0.01% w/w) and AV (0.5% v/v) were added to the prepared polymer solution. As prepared solution was cross‐linked by β‐GP with the weight ratio of 1/6 w/w (1 chitosan and 6 β‐GP). The characterization of the hydrogels showed that the hydrogels have porous structures and interconnected pores with the pores size range from 41.5 ± 14 to 48.3 ± 11 μm. The swelling and weight loss measurements of the hydrogels showed that the hydrogels could swell up to 240% of their initial weight during 8 h and loss 79.7 ± 3.5% of the initial weight during 14 days. The antibacterial studies depicted that the prepared Cs/tEDTA/AV hydrogel inhibited the growth of Staphylococcus aureus (the minimum inhibition concentration, MIC of 73 ± 4.8) and Pseudomonas aeruginosa (the MIC of 40 ± 7.9). Moreover, the prepared hydrogels were hemocompatible (Cs/tEDTA/AV: OD of 0.24 ± 0.30) and biocompatible (Cs/tEDTA/AV: OD of 0.38 ± 0.01). At the final stage, the wound healing assessments in the animal model revealed that the application of the prepared hydrogels effectively enhanced the wound healing process. In conclusion, the results confirmed the efficacy of the prepared hydrogels as the wound healing materials.

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“…[ 14 ] A collagen hydrogel loaded with naringin can aid the healing process of the induced nerve injury with well‐arranged fibers and intact myelin sheath. [ 15 ] A salicylic‐acid‐based poly(anhydride‐ester) NGC acts as both a drug delivery vehicle capable of reducing inflammation and a tissue scaffold that promotes the peripheral nerve regeneration and functional recovery. [ 16 ] Chitosan conduits filled with simvastatin/Pluronic F‐127 hydrogel can promote the peripheral nerve regeneration in rats by increase in the compound muscle action potential peak amplitude, motor nerve conduction velocity (NCV), myelin sheath thickness, axon diameter, and gastrocnemius wet weight.…”

Section: Introductionmentioning

confidence: 99%

Methylcobalamin‐Loaded PLCL Conduits Facilitate the Peripheral Nerve Regeneration

Zhang

Yang

Wang

et al. 2020

Macromolecular Bioscience

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The feasible fabrication of nerve guidance conduits (NGCs) with good biological performance is important for translation in clinics. In this study, poly(d,l‐lactide‐co‐caprolactone) (PLCL) films loaded with various amounts (wt; 5%, 15%, 25%) of methylcobalamin (MeCbl) are prepared, and are further rolled and sutured to obtain MeCbl‐loaded NGCs. The MeCbl can be released in a sustainable manner up to 21 days. The proliferation and elongation of Schwann cells, and the proliferation of Neuro2a cells are enhanced on these MeCbl‐loaded films. The MeCbl‐loaded NGCs are implanted into rats to induce the regeneration of 10 mm amputated sciatic nerve defects, showing the ability to facilitate the recovery of motor and sensory function, and to promote myelination in peripheral nerve regeneration. In particular, the 15% MeCbl‐loaded PLCL conduit exhibits the most satisfactory recovery of sciatic nerves in rats with the largest diameter and thickest myelinated fibers.

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Sciatic nerve regeneration by using collagen type I hydrogel containing naringin

Cited by 46 publications

References 42 publications

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

Chitosan hydrogel loaded with Aloe vera gel and tetrasodium ethylenediaminetetraacetic acid (EDTA) as the wound healing material: in vitro and in vivo study

Methylcobalamin‐Loaded PLCL Conduits Facilitate the Peripheral Nerve Regeneration

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