Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Fernandes, Thiago P.; Shaqiri, Albulena; Brand, Andreas; Nogueira, Renata L.; Herzog, Michael H.; Roinishvili, Maya; Santos, Natanael Antônio dos; Chkonia, Eka

doi:10.1016/j.psychres.2019.03.008

Cited by 25 publications

(24 citation statements)

References 61 publications

(67 reference statements)

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“…The analysis showed that, overall, results were comparable to the ones obtained in the main analysis (results are shown and discussed in supplementary Tables S4, S5, and S6). Third, severity of the disorder and medications can introduce confounding factors (74)(75)(76). Generally, severity (BPRS) did not correlate with masking outcomes, in particular in BP (supplementary Table S7, left).…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

Garobbio

Roinishvili

Favrod

et al. 2020

Preprint

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Background:In visual backward masking (VBM), a target is followed by a mask that decreases target discriminability. Schizophrenia patients (SZ) show strong and reproducible masking impairments, which are associated with reduced EEG amplitudes. Patients with bipolar disorder (BP) show masking deficits, too. Here, we investigated the neural EEG correlates of VBM in BP.Methods: 122 SZ, 94 unaffected controls, and 38 BP joined a standard VBM experiment. 123 SZ, 94 unaffected controls and 16 BP joined a corresponding EEG experiment, analyzed in terms of the global field power. Results:As in previous studies, SZ and BP show strong masking deficits. Importantly and similarly to SZ, BP show decreased global field power amplitudes at approximately 200 ms after the target onset, compared to controls. Conclusions:These results suggest that VBM deficits are not specific for schizophrenia but for a broader range of functional psychoses. Potentially, both SZ and BP show deficient target enhancement.

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Section: Discussionmentioning

confidence: 99%

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

Garobbio

Roinishvili

Favrod

et al. 2020

Preprint

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“…Further details about medication can be found in the precursor study. 1 Chlorpromazine equivalents were calculated using previously described conversion factors. [5][6][7] The healthy controls were recruited from the general population.…”

Section: Participantsmentioning

confidence: 99%

“…The contrast sensitivity function was measured for spatial frequencies ranging from 0.2 to 20 cpd using linear sine-wave gratings. The stimuli and apparatus have been described elsewhere (for details, see Fernandes et al 1,4,11 ).…”

Section: Stimuli and Apparatusmentioning

confidence: 99%

“…Mixed results in previous studies investigating the effects of medication on visual function in SCZ have led to more comprehensive research in recent years. Fernandes et al 1 investigated the effects of antipsychotics on a variety of visual and cognitive tasks. Patients on typical and atypical antipsychotics were carefully selected and tested in two studies.…”

Section: Introductionmentioning

confidence: 99%

“…As an extension of the work of Fernandes et al, 1 the present study sought to investigate the combined effects (interaction) of illness duration and medication type on visual impairment using a wide range of spatial frequencies. According to previous findings, contrast sensitivity function (CSF) has potential as a non-invasive diagnostic tool for clinical practice, being an alternative or adjuvant to existing tools and providing a quick and thorough investigation of initial visual processing.…”

Section: Introductionmentioning

confidence: 99%

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Combined influence of illness duration and medication type on visual sensitivity in schizophrenia

Almeida

Fernandes

Lima

et al. 2020

Braz. J. Psychiatry

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Objective: Patients with schizophrenia have visual processing impairments. The main findings from the literature indicate that these deficits may be related to differences in paradigms, medications, and illness duration. This study is part of a large-scale study investigating visual sensitivity in schizophrenia. Here we aimed to investigate the combined effects of illness duration and antipsychotic use on contrast sensitivity function. Methods: Data were collected from 50 healthy controls and 50 outpatients with schizophrenia (classified according to illness duration and medication type) aged 20-45 years old. The contrast sensitivity function was measured for spatial frequencies ranging from 0.2 to 20 cycles per degree using linear sine-wave gratings. Results: Patients with an illness duration 4 5 years had more pronounced deficits. Differences in the combined effects of illness duration and antipsychotic use were marked in patients on typical antipsychotics who had been ill 4 10 years. No significant differences were found between typical and atypical antipsychotics in patients with an illness duration o 5 years. Conclusion: Visual impairment was related to both long illness duration and medication type. These results should be tested in further studies to investigate pharmacological mechanisms.

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Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Cited by 25 publications

References 61 publications

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

Combined influence of illness duration and medication type on visual sensitivity in schizophrenia

Available Treatment Modules for Brain Disorders

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