Schizophrenia: A Disorder of Timing and Sensorimotor Integration During Decision-Making

Bittencourt, Juliana; Velasques, Bruna; Teixeira, Silmar; Aprigio, Danielle; Gongora, Mariana; Cagy, Maurício; Fernandes, Thayaná Ribeiro Silva; Ribeiro, Pedro; Marinho, Victor

doi:10.1007/978-3-030-96814-4_6

Cited by 2 publications

(3 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, being Gq/11-proteincoupled receptor, 5-HT2AR stimulation increases phospholipase C (PLC) activity, an enzyme that hydrolyzes phosphatidyl inositol diphosphate (PIP2) into inositol triphosphate (IP3) and diacylglycerol (DAG); IP3 mobilizes calcium from the endoplasmic reticulum, increasing cytosolic calcium concentration, which could explain the central excitatory effects [45]. Judgment disorders that occur in schizophrenia or after the use of psychotropic substances surface as a result of changes in sensorimotor integration and decision-making [46]. pled receptor, 5-HT2AR stimulation increases phospholipase C (PLC) activity, an enzyme that hydrolyzes phosphatidyl inositol diphosphate (PIP2) into inositol triphosphate (IP3) and diacylglycerol (DAG); IP3 mobilizes calcium from the endoplasmic reticulum, increasing cytosolic calcium concentration, which could explain the central excitatory effects [45].…”

Section: Benzydamine As Serotonin Receptor Modulatormentioning

confidence: 99%

“…pled receptor, 5-HT2AR stimulation increases phospholipase C (PLC) activity, an enzyme that hydrolyzes phosphatidyl inositol diphosphate (PIP2) into inositol triphosphate (IP3) and diacylglycerol (DAG); IP3 mobilizes calcium from the endoplasmic reticulum, increasing cytosolic calcium concentration, which could explain the central excitatory effects [45]. Judgment disorders that occur in schizophrenia or after the use of psychotropic substances surface as a result of changes in sensorimotor integration and decision-making [46]. In the regions of sensorimotor integration, 5-HT2AR interacts with dopamine D2 receptors (D2R), with stimulation of serotonin receptors contributing to an increase in dopamine concentration in the prefrontal cortex [47] and in the ventral striatum, more precisely the nucleus accumbens [48].…”

Section: Benzydamine As Serotonin Receptor Modulatormentioning

confidence: 99%

See 1 more Smart Citation

Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

et al. 2023

View full text Add to dashboard Cite

Benzydamine is a non-steroidal anti-inflammatory drug with distinct pharmacological properties from other compounds in the same therapeutic class. The differences are structural and pharmacological in nature; the anti-inflammatory mechanism is not strictly explained by the ability to interfere with the synthesis of prostaglandins. The compound is used strictly in local inflammatory diseases (inflammation in the oral and vaginal mucosa). In addition to the therapeutic indications found in the summary of product characteristics (SPC), the compound is used, in high doses, as a psychotropic substance for oral administration, having similar properties to lysergic acid diethylamide (LSD). As an over-the-counter (OTC) compound, it is easy to obtain, and the consequences of using it for purposes other than those assumed by the manufacturer raise various concerns. The reasons are related to the pharmacodynamic and pharmaco-toxicological properties, since neither the mechanism of action nor the possible side effects that would result from systemic consumption, in high doses, even occasionally, have been fully elucidated. The present review aims to analyze the pharmacodynamic properties of benzydamine, starting from the chemical structure, by comparison with structurally similar compounds registered in therapy (as an anti-inflammatory or analgesic) or used for recreational purposes.

show abstract

Section: Benzydamine As Serotonin Receptor Modulatormentioning

confidence: 99%

Section: Benzydamine As Serotonin Receptor Modulatormentioning

confidence: 99%

Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

et al. 2023

View full text Add to dashboard Cite

show abstract

“…In schizophrenia, the body is experienced mainly as an external object rather than an integral dimension of an embodied subject (Sass & Parnas, 2003). Persons with schizophrenia demonstrate some typical disturbances in experiencing their own body: their sense of being alive is reduced (e.g., the body is experienced as dead, numb or insensitive), they perceive their bodies as deformed, unreal or dismembered (Rohricht et al, 2010;Rohricht & Priebe, 2002) and they demonstrate weakened sensorimotor integration mechanisms (Bittencourt et al, 2022;Carter et al, 2017). Additionally, they show disruptions in the processing of information in the attention monitoring system, leading to many disruptions in the experience of their own body, such as abnormal body awareness manifesting itself in motor inhibition and disruption of the sense of self (McGhie & Chapman, 1961).…”

Section: Introductionmentioning

confidence: 99%

Mental Representations of the Body and Malleability of the Sense of Body Ownership in Schizophrenia within the Embodied Subject Model

Mirucka,

Kisielewska

2023

KiE

View full text Add to dashboard Cite

The presented study was intended to shed some new light on the disturbance of body experience in persons with schizophrenia in reference to the Embodied Subject Model. The model proposes to complement theoretical linkages between concepts related to bodiness – body self and mental representations of the body (body schema, body image, body awareness) and a relatively new concept of body identity. The main research questions were: Given that persons with schizophrenia are characterised by the painful experience of their body as an external object, would they also manifest i/ weakened sensorimotor integration mechanisms, ii/ disordered mental representations of the body, iii/ weakened sense of body ownership? 41 individuals with schizophrenia and 41 matched controls participated in the Rubber Hand Illusion procedure. Body representations were measured with a Battery of Tests of the Body Self Representations. The individuals with schizophrenia showed lower scores in three body representations and greater susceptibility to the rubber hand illusion. It suggests that the explanation of susceptibility to disturbances in the sense of body ownership should be focused on the deficient structure of mental representations of the body.

show abstract

Schizophrenia: A Disorder of Timing and Sensorimotor Integration During Decision-Making

Cited by 2 publications

References 96 publications

Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

Mental Representations of the Body and Malleability of the Sense of Body Ownership in Schizophrenia within the Embodied Subject Model

Contact Info

Product

Resources

About