Schistosomiasis vaccines

Siddiqui, Afzal A.; Siddiqui, Bilal A.; Ganley-Leal, Lisa

doi:10.4161/hv.7.11.17017

Cited by 73 publications

(60 citation statements)

References 71 publications

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“…Schistosomiasis is a chronic disease, endemic in 78 countries of the developing world, affecting 391-597 million people worldwide, with 800 million at risk of the infection [1][2][3] . Currently, treatment for schistosomiasis mainly relies upon praziquantel (PZQ) which is effective against all the species of human schistosomes 4 .…”

Section: Introductionmentioning

confidence: 99%

Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production

Allam

Abuelsaad

Alblihed

et al. 2016

Immunopharmacology and Immunotoxicology

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Section: Introductionmentioning

confidence: 99%

Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production

Allam

Abuelsaad

Alblihed

et al. 2016

Immunopharmacology and Immunotoxicology

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“…Schistosoma mansoni infects over 83 million people in Africa and the Middle East (Criscione et al, 2009). Recent articles documented the infection of 391-597 million people, with 800 million, mostly children, at risk of the infection (King 2010, andSiddiqui et al, 2011). Hotez et al, in 2012 was reported that Egypt is the MENA (Middle East North African) country with the highest prevalence (7.2 out of 80.4 million people, about 9%) of schistosomiasis, in spite of the many efforts to control this parasitic infection over many years ago (El-Khoby et al, 2000).…”

Section: Introduction:-mentioning

confidence: 99%

Antiparasitic and physiological evaluation of Curcuma longa extract and/or PZQ on Schistosoma mansoni infected mice.

Aboueldahab¹,

Elhussieny.²

2016

IJAR

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Praziquantel (PZQ) is the drug of choice against schistosomiasis. However, PZQ was found not fully effective. A new trend from natural plant sources was used to compete schistosomiasis. In the present study, the antischistosomal activities of Curcumin extract and /or PZQ were evaluated. Parasitological and histopathological examination of liver has been explored. Moreover, Surface topography of the recovered worms was inspected by SEM. On the other hand, the total protein and DNA fragmentation percentage were estimated in infected and infected treated mice as compared to control group. Treatment of infected CD1 mice with curcumin extract alone didn't show any detectable changes in the parasitological or histological parameters. The infected mice treated with PZQ only, showed a significant decrease in the total worm burden, egg load (52%), with increase in degenerated eggs (58%) in the oogram pattern.However, treating infected CD1 mice with combined therapy (curcumin extract + PZQ) showed extremely significant reduction in female and male worm count (93% & 84%) respectively. Liver tissue egg load decreased by 88%, intestinal egg load decreased by 97%. Combined therapy decreased granuloma count and diameter with significant increase in degenerated egg in the oogram count. Moreover, the studied biomarkers, related to liver function and DNA damage were significantly improved in infected mice treated with curcumin combined with PZQ as compared to either drug alone. . In conclusion, curcumin extract in combination with PZQ has a synergetic effect and could be more promising in controlling schistosomiasis.Copy Right, IJAR, 2016,. All rights reserved.

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“…How to reduce mortality and morbidity rates due to schistosomiasis among residents in the endemic areas of the world depends mainly on improvement of public hygiene, chemotherapy and the potential addition of vaccines (Siddiqui et al, 2011). However, control activities has started to shift its focus from morbidity to transmission and the latter is rapidly becoming a critical task for many tropical countries, which requires well-established systems for monitoring surrounding environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Study of the variation of schistosomiasis risk in Lake Poyang in the People’s Republic of China using multiple space-borne sensors for monitoring and modelling

et al. 2014

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Abstract. The dynamics of the Poyang Lake in Jiangxi province, People's Republic of China has been monitored to demonstrate the association of various variables with the distribution of schistosomiasis transmission with particular reference to the annual variation of the habitats for the Oncomelania snail, the intermediate host of Schistosoma japonicum. This was studied with multiple space-borne sensors, including the ENVISAT radar altimeter (RA-2) and MODIS/Terra radiometry data products such as the 16-day enhanced vegetation index, the 8-day sun reflectance, and the derived modified normalized difference water index. The measurements of physical properties were in good accordance with previous reports based on in situ gauge data, spectroradiometry and other optical methods, which encouraged us to build a predictive model based on reported geospatial constraints to assess the limits of potential variation of the snail habitat areas. The simulated results correspond fairly well with surveys conducted by local authorities showing a correlation coefficient of 0.82 between highpotential habitat areas and local estimates in a 9-year (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010) analysis. Taken together, these data indicate that spaceborne observations and in situ measurements can be integrated and used as a first step of a monitoring system for control and analysis of the potential of schistosomiasis dissemination. Since the true range and intensity of transmission in the study region remain elusive at present, a long-term survey around the lake is warranted to build a robust, parametric model.

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Schistosomiasis vaccines

Cited by 73 publications

References 71 publications

Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production

Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production

Antiparasitic and physiological evaluation of Curcuma longa extract and/or PZQ on Schistosoma mansoni infected mice.

Study of the variation of schistosomiasis risk in Lake Poyang in the People’s Republic of China using multiple space-borne sensors for monitoring and modelling

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