Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice

Abstract

The effects of schisandrin B (Sch B) on liver and serum lipid contents were investigated in mice with experimentally-induced hypercholesterolaemia. Hypercholesterolaemia was induced either by oral administration of a cholesterol/bile salts mixture (2/0.5 g kg(-1)) for four days or by feeding a high fat/cholesterol/bile salts (10/1/0.3%, w/w) diet for seven days. Daily co-administration of Sch B (50-200 mg kg(-1), i.g.) for four or six days, respectively, decreased hepatic total cholesterol (TC) and triglyceride (TG) levels (by up to 50% and 52%, respectively) in hypercholesterolaemic mice. Sch B treatment also increased hepatic indices (14-84%) in hypercholesterolaemic mice. The results indicated that Sch B treatment could decrease hepatic TC and TG levels, and increase liver weight, in mouse models of hypercholesterolaemia. Fenofibrate treatment (100 mg kg(-1)) produced effects similar to those of Sch B on the hepatic index and lipid levels of hypercholesterolaemic mice.

The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies

“…They are known to have several biological features that help prevent hyperglycemia, hepatotoxicity and inflammation (Pan et al, 2008;Stacchiotti et al, 2009;Zhang et al, 2010). Gomisin J, gomisin N, schizandrin A and schizandrin C among lignans isolated Schisandrae chinensis significantly increase basal glucose uptake in HepG2 cells, and gomisin N especially was found to have a stronger effect than RGZ (Zhang et al, 2010).…”

“…In addition, schizandrin B has beneficial effects on the liver when damage is induced by CCl 4 and mercuric chloride by improving antioxidative capacity and decreasing endoplasmic reticulum stress, respectively (Chang et al, 2009;Stacchiotti et al, 2009). Schizandrin B reduces hepatic lipid contents in hypercholesterolaemic mice (Pan et al, 2008). Therefore, schizandrins and gomisins possibly ameliorate insulin resistance and protect against the development of diabetes.…”

Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: Effects on serum lipid profiles and blood pressure

“…These results indicate that the rodent model for studying lipid metabolism physiology may have some limitations, but it still provides a good model for studying the effects of estrogenic substances on TC and LDL-C levels. Previously, schisandrin B, which was isolated from the fruit of Schizandra chinensis, significantly lowered serum LDL-C levels, but this effect was abolished in serum TC for diet-induced hypercholesterolemic rodents (Pan et al, 2006(Pan et al, , 2008. Additionally, Shengmai San, which is a traditional Chinese medicine composed of Schizandra chinensis and other medicinal herbs, had no effect on plasma lipid levels (Yao et al, 2008).…”

Schisandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study

“…Schisandra chinensis fruit inhibited preadipocyte differentiation and adipogenesis in 3T3-L1 cells, leading to decreased body weight and fat mass in high-fat dietinduced obese rats [13]. In addition, dibenzocylooctadiene lignans from SCF have fatty acid synthase inhibitory activity, [14] and schisandrin B isolated from SCF reduces hepatic lipid contents in hypercholesterolemic mice [15]. The influence of gut microbiota in high-fat diet rats has also been reported and an increase in Bifidobacterium and a decrease in Clostridium species [16].…”