Schisandra chinensis-derived gomisin C suppreses lipid accumulation by JAK2-STAT signaling in adipocyte

You, Ye-Lim; Lee, Ji-Yeon; Hyun-Min, Choi

doi:10.1007/s10068-023-01263-8

Cited by 3 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidant activity is also affected by the position and number of tigloyl, angeloyl, hydroxyl, and benzoyl groups on the cyclooctadiene ring [ 16 ]. It was previously reported that (+)-gomisin A ( 11 ) [ 41 ] and (−)-gomisin C ( 4 ) [ 42 ] showed good antioxidant effects, but it was not confirmed in our experiment. Also, other previously published studies described (+)-deoxyschisandrin ( 6 ) (syn.…”

Section: Resultscontrasting

confidence: 89%

See 1 more Smart Citation

Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

Rybnikář,

Malaník,

Šmejkal

et al. 2024

IJMS

View full text Add to dashboard Cite

Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-κB activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (−)-gomisin N, (+)-γ-schisandrin, rubrisandrin A, and (−)-gomisin J.

show abstract

Section: Resultscontrasting

confidence: 89%

“…Oxidative stress can be induced with high glucose levels [ 41 ], H 2 O 2 [ 43 ], or tert -butyl hydroperoxide [ 44 ]. You et al did not generate stress but measured the ability of compound 4 to decrease the basal level of stress in adipocytes [ 42 ].…”

Section: Resultsmentioning

confidence: 99%