Scenario of the Treatment of Arthritis with Natural Products

Gallotti, Fernanda Costa Martins; Serafini, Mairim Russo; Thomazzi, Sara Maria

doi:10.2174/1872213x14666200228103001

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…Modulation of inflammation with the use of medicinal plant extracts and their main substances serve as a complementary tool for conventional therapeutic strategies for numerous ailments, particularly when the suppression of inflammation is expected (Gallotti et al, 2020). In up-to-date literature, several species of medicinal plants have been shown substantial anti-inflammatory and immunomodulatory actions including inhibitory effects on the suppression of cellular and humoral immunity, lymphocyte activation, and the propagation of apoptosis (Tasneem et al, 2019;Zhao et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Effect of Saffron Extract, Astaxanthin, and Carnosic Acid on the Levels of Matrix Metalloproteinase-9 and on Body Weight Changes in Arthritis Experiments

Martin

Silvester

František

et al. 2022

European Pharmaceutical Journal

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AIM The aim of this study was to explore the potential effect of natural compounds and their combination with methotrexate (M) on levels of matrix metalloproteinase-9 (MMP-9) as a key biochemical parameter in rat adjuvant arthritis. Further change of body weight was selected as one of clinical parameters monitored in this animal model. MATERIALS AND METHODS Adjuvant arthritis (AA) was induced in Lewis rats. Methotrexate (M) was administrated twice a week in a dose of 0.3 mg/kg b.w. The saffron extract was administrated daily in two doses: 25 mg/kg b.w. (SF1) and 50 mg/kg b.w. (SF2). Both doses were administrated alone and in combination with M. Astaxanthin was administrated also daily in two doses: 1 mg/kg b.w. (AS1) and 5 mg/kg b.w. (AS2) only as monotherapy. Carnosic acid was administrated daily in one dose: 100 mg/kg (C) in monotherapy and in combination with M. All compounds and M were administrated orally. Plasma samples were collected on the 21st experimental day and used for ELISA determination. The 21st experimental day was used also for the analysis of body weight changes. RESULTS We observed a significant decrease of MMP-9 plasmatic levels in SF1 and SF2 monotherapy in AA animal groups. The decrease in levels of MMP-9 in combined therapy of SF1 and M had higher significance than the effect of M only in AA. The same decreasing effect on the levels of MMP-9 was observed in the combined therapy of C and M. Astaxanthin and saffron extract had a very similar effect on clinical parameters and the change in body weight: both have significantly increased body weight in monotherapy in both doses used. The combined therapy of M and saffron extract doses showed no significant difference from M itself. Carnosic acid did not affect the change of body weight, and the combination of C with M reached the same level as M alone. CONCLUSION Astaxanthin in monotherapy and saffron extract in monotherapy and in combined therapy with M have significantly decreased plasmatic levels of MMP-9 and increased body weight in animals suffering from AA. Lower doses were more efficient for both experiments: astaxanthin and saffron extract. Carnosic acid has no effect in monotherapy in both parameters, but a combination with M has a significant effect with respect to the improvement of cachexia as well as the inhibition of inflammation.

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Section: Discussionmentioning

confidence: 99%

Effect of Saffron Extract, Astaxanthin, and Carnosic Acid on the Levels of Matrix Metalloproteinase-9 and on Body Weight Changes in Arthritis Experiments

Martin

Silvester

František

et al. 2022

European Pharmaceutical Journal

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“…Researchers have studied natural products for OA and RA for a long time [54][55][56]. Herbal medications have shown the potential for safe and effective management of arthritis.…”

Section: Known Natural Compounds For the Prevention And Treatment Of ...mentioning

confidence: 99%

Herbal remedies as a potential alternative therapy for arthritis

Künnemann,

Trivedi,

Roja

2023

Academia Biology

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The use of natural compounds has been significant for human health since centuries. However, only with molecular techniques and cell biology experiments, the function of these interactions can be shown and their therapeutic use in medicine be proven. In this review, we show the pathology of osteoarthritis and rheumatoid arthritis, a disease condition affecting millions of people worldwide and we describe herbal materials that are used for arthritis treatment. In detail, we describe how different plant substances, that is, curcumin and several ingredients of rosehip, can interact with cartilage compounds and reduce the inflammatory reaction by specifically interacting with cellular pathways. Arthritis forms a vicious cycle, where upon overuse of a joint or an autoimmune reaction inflammation and pain occur. These are marked by specific molecular patterns and immunological pathways that lead to chondrolysis and destruction of cartilage. Natural plant substances can influence these pathways and help to break out of the vicious cycle and to find a way for stopping the disease or even to regenerate and heal injured cartilage. In conclusion, rosehip, curcumin and other natural remedies are effective treatments and combinations are possible. Bioavailability of the substances is important and can be increased with specific enhancers. We also discuss that targeting pain only without treating cartilage degeneration can lead to unnoticed further irreparable decay and advice to treat pain and joint health at once. Additionally, regular movement of the joints is necessary for natural compounds to act in the human body and provide wellness.

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“…Its symptoms are usually characterized by pain, functional weakness, and primary disability in more advanced stages. These conditions impose a substantial burden on individuals, the health system, and society since it is not effectively treatable [1][2][3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

The Effects of Curcuma Longa on the Osteoarthritis: A Systematic Review of Placebo-Controlled Clinical Studies

Alvarenga

Marconato

Fracaro

et al. 2022

MRAJ

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Osteoarthritis (OA) is a joint disorder characterized by chronic, degenerative, and irreversible inflammation leading to pain and disability. The standard drugs are ineffective for many patients and are usually associated with numerous side effects such as gastrointestinal complaints. Curcuma longa and its bioactive compounds have been considered for OA. The objective of this study was to perform a systematic review of the effects of Curcuma longa and its derivatives on OA. Pubmed, Cochrane, and Embase were searched, and PRISMA guidelines were followed to build this review. Only Randomized Clinical Trials (RCTs) that performed placebo-comparison were included. Most included studies showed that Curcuma longa or formulations prepared with curcuminoids can benefit the OA scores such as Visual Analog Scale, Knee injury and Osteoarthritis Outcome Score, Western Ontario and McMaster Universities Osteoarthritis Index; and Lequesne's pain functional index. The use of Curcuma longa extracts or curcuminoids can benefit patients with OA. Nevertheless, the available RCTs show treatment time, doses, and formulations heterogeneity. Thus, the standardization of RCTs can guide researchers and physicians on the dosages and formulations that are most effective in addressing this condition, which is very prevalent in the world's populations.

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Scenario of the Treatment of Arthritis with Natural Products

Cited by 5 publications

References 47 publications

Effect of Saffron Extract, Astaxanthin, and Carnosic Acid on the Levels of Matrix Metalloproteinase-9 and on Body Weight Changes in Arthritis Experiments

Effect of Saffron Extract, Astaxanthin, and Carnosic Acid on the Levels of Matrix Metalloproteinase-9 and on Body Weight Changes in Arthritis Experiments

Herbal remedies as a potential alternative therapy for arthritis

The Effects of Curcuma Longa on the Osteoarthritis: A Systematic Review of Placebo-Controlled Clinical Studies

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