volume 55, issue 7, P1730-1740 1990
DOI: 10.1135/cccc19901730
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Abstract: Our philosophy of successful biotechnology transfer to industrial scale covers the comparison of complex sets of microbiological, analytical and bioengineering data from cultivations in various scales and different geometries of mixing with laboratory findings. In particular, the availability of nutrients to producing microorganism should be understood, therefore for quick scaling-up procedure of polyene antibiotics produced by Streptomyces noursei we recommend to use physiological marker as total dehydrogenas…

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