Scaffolds from electrospun polyhydroxyalkanoate copolymers: Fabrication, characterization, bioabsorption and tissue response

Ying, Tang; Ishii, Daisuke; Mahara, Atsushi; Murakami, Shuta; Yamaoka, Tetsuji; Sudesh, Kumar; Samian, Razip; Fujita, Masahiro; Maeda, Mizuo; Iwata, Tadahisa

doi:10.1016/j.biomaterials.2007.11.031

Cited by 144 publications

(86 citation statements)

References 35 publications

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“…It is well known that P(3HB) crystallizes as an orthorhombic crystal system with unit cell parameters of a = 0.576 nm, b = 1.320 nm, and c(fiber axis) = 0.598 nm and space group P2 1 2 1 2 1 (a-structure; Yokouchi et al 1973), and that the b-structure introduces from the orientation of free chains in amorphous regions between a-structure lamellar crystals; that is, the development of the b-structure is not really a transformation from the a-structure (Orts et al 1990;Iwata et al 2003Iwata et al , 2005Iwata 2005). More recently, Iwata et al (2008) reported a 3D crystal structure of the b-structure that has lattice parameters of a = 0.528 nm, b = 0.920 nm, and c(fiber axis) = 0.469 nm as an orthorhombic crystal system. Fig.…”

Section: Structure Analysismentioning

confidence: 98%

Manufacturing of PHA as Fibers

Iwata

Tanaka

2009

Microbiology Monographs

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Poly[(R)-3-hydroxybutyrate] and its copolymers have not been recognized as practical because of its stiffness and brittleness. Recently, we succeeded in obtaining strong fibers by two kinds of new drawing techniques from microbial polyesters produced by both wild-type and recombinant bacteria. The improvement of the mechanical properties of fibers is due not only to the orientation of the molecular chains but is also due to the generation of a planar zigzag conformation. The highly ordered and inner structures of strong fibers with tensile strength of over 1.0 GPa were analyzed by microbeam X-ray diffraction and X-ray microtomography

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Section: Structure Analysismentioning

confidence: 98%

Manufacturing of PHA as Fibers

Iwata

Tanaka

2009

Microbiology Monographs

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“…28 Therefore, the longer stability of the ejected charged jet leads to fewer numbers of pores and thicker bridges. 29 For more, it is probable for the upper layers to overlap the pores of the layer beneath, and a greater reduction is expected in pore interconnectivity.…”

Section: Polymer Concentrationmentioning

confidence: 99%

Experimental investigation of the governing parameters in the electrospinning of poly(3‐hydroxybutyrate) scaffolds: Structural characteristics of the pores

Tehrani

Ali

Karbasi

et al. 2010

J of Applied Polymer Sci

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We sought to determine the impact of electrospinning parameters on a trustworthy criterion that could evidently improve the maximum applicability of fibrous scaffolds for tissue regeneration. We used an image analysis technique to elucidate the web permeability index (WPI) by modeling the formation of electrospun scaffolds. Poly(3-hydroxybutyrate) (P3HB) scaffolds were fabricated according to predetermined conditions of levels in a Taguchi orthogonal design. The material parameters were the polymer concentration, conductivity, and volatility of the solution. The processing parameters were the applied voltage and nozzle-to-collector distance. With a law to monitor the WPI values when the polymer concentration or the applied voltage was increased, the pore interconnectivity was decreased. The quality of the jet instability altered the pore numbers, areas, and other structural characteristics, all of which determined the scaffold porosity and aperture interconnectivity. An initial drastic increase was observed in the WPI values because of the chain entanglement phenomenon above a 6 wt % P3HB content. Although the solution mixture significantly (p < 0.05) changed the scaffold architectural characteristics as a function of the solution viscosity and surface tension, it had a minor impact on the WPI values. The solution mixture gained the third place of significance, and the distance was approved as the least important factor.

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“…К его недостаткам можно отнести риск закисления тканей в про-цессе деградации [2,7]. Полигидроксиалканоа-ты -линейные полимеры, получаемые микробио-логическим путем, при этом в силу особенностей биосинтеза, характеризуются широким спектром значений скорости деградации и механических параметров, что позволяет применять полиокси-алканоаты в различных областях медицинской науки и практики [8,13,21]. В то же время из-вестно, что обладая высокой биосовместимостью, полигидроксибутират характеризуется достаточ-ной хрупкостью и невысокой прочностью.…”

Section: Introductionunclassified

Influence of Composition and Concentration of Biodegradable Polymers on Structure and Physico-Mechanical Properties of Electrospun Scaffolds

Шишкова¹,

Насонова²,

Ходыревская³

et al. 2016

Kompleks. probl. serdečno-sosud. zabol.

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Результаты. Концентрация раствора полимера значительно влияет на диаметр волокон, формируемых в процессе ЭС, при этом не оказывая существенного влияния на размер образуемых пор. Использование 6 % раствора полимеров не позволяет полу-чать полноценные волокна, что негативно отражается на их морфологии и физико-механических свойствах. для создания матриц на основе ПгБВ, ПлА и ПКл оптимальнее всего использовать концентрацию раствора 8-10 %. добавление к ПгБВ ПлА уменьшает диаметр волокон и размер пор, а включение в полимерную композицию ПлА приводит к увеличению эластичности матриц.Заключение. Состав полимерной композиции и концентрация раствора оказывают существенное влияние на размер пор, структуру и диаметр волокон, формируемых в процессе электроспиннинга, что в свою очередь сказывается на физико-механиче-ских свойствах получаемых матриц.Ключевые слова: матрицы, биодеградируемые полимеры, электроспиннинг, пористость. Purpose. to investigate the composition and concentration of the polymer solutions on structure and physico-mechanical properties of the electrospun scaffolds. INFLUENCE OF COMPOSITION AND CONCENTRATION OF BIODEGRADABLE POLYMERS ON STRUCTURE AND PHYSICO-MECHANICAL PROPERTIES OF ELECTROSPUN SCAFFOLDSMaterials and methods. We prepared electrospun scaffolds from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), polycaprolactone (PCL), and poly(d,L-lactide) (PLA) in concentrations of 6, 8, and 10 %. We investigated mechanical properties of the scaffolds, fiber diameter, and pore size.

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Scaffolds from electrospun polyhydroxyalkanoate copolymers: Fabrication, characterization, bioabsorption and tissue response

Cited by 144 publications

References 35 publications

Manufacturing of PHA as Fibers

Manufacturing of PHA as Fibers

Experimental investigation of the governing parameters in the electrospinning of poly(3‐hydroxybutyrate) scaffolds: Structural characteristics of the pores

Influence of Composition and Concentration of Biodegradable Polymers on Structure and Physico-Mechanical Properties of Electrospun Scaffolds

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