SARS-CoV2 RNA detection in a pancreatic pseudocyst sample

Schepis, Tommaso; Larghi, Alberto; Papa, Alfredo; Miele, Luca; Panzuto, Francesco; Biase, Luciano De; Annibale, Bruno; Cattani, Paola; Rapaccini, Gian Ludovico

doi:10.1016/j.pan.2020.05.016

Cited by 71 publications

(74 citation statements)

References 7 publications

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“…[ 54 ](Romania) Case report ✚ ✚ Edematous pancreas Clinical AP Schepis et al. [ 46 ](Italy) Case report — ✚ Pseudocyst of pancreas Cyst fluid positive for SARS-CoV-2 karimzadeh et al. [ 40 ](Iran) Case report ✚ ✚ Normal No respiratory symptoms Rabice et al.…”

Section: Real World Data Of Covid-19 and Pancreatic Injurymentioning

confidence: 99%

“…Schepis et al. [ 46 ] described an intriguing finding of SARS-CoV-2 positivity in pancreatic pseudocyst sample of a follow-up case of AP presenting with pain abdomen and chest infiltrates. This finding is interesting as SARS-CoV-2 has already been detected in various body fluids such as urine and blood besides respiratory aerosols.…”

Section: Real World Data Of Covid-19 and Pancreatic Injurymentioning

confidence: 99%

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Coronavirus disease 2019 and the pancreas

et al. 2020

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Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to a world-wide pandemic since its onset in December of 2019. Although, a primary respiratory pathogen, over the ensuing period, its extra-pulmonary effects have come to the forefront. The virus, having multi-organ tropism, has been shown to affect a host of other organs beyond the lung, including the pancreas. The data on pancreatic involvement by COVID-19, however, have been limited. Moreover, whether the effects on the pancreas are due to the direct effects of the virus or is just an epi-phenomenon is debatable. The prevalence of pancreatic injury and degree of injury are the other issues that need to be addressed. Pancreatic cancer has a dismal prognosis and the management of the same in the COVID era needs to be tailored assessing the risk-benefit ratio for the same. Additionally, pancreatic surgery increases not only the morbidity of the patient, but also the risk of the operator and burden on the health care system. Hence, the decision for such major procedures needs to be rationalized for optimum benefit during this pandemic. Similarly, for the endoscopist, pancreatic endoscopy needs to be carefully regulated to reduce risk to both the patient and the physician and yet deliver optimum patient care. This review gives a concise summary of various aspects of pancreatic involvement and pancreatic disease management during this pandemic.

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Section: Real World Data Of Covid-19 and Pancreatic Injurymentioning

confidence: 99%

Section: Real World Data Of Covid-19 and Pancreatic Injurymentioning

confidence: 99%

Coronavirus disease 2019 and the pancreas

et al. 2020

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“…SARS CoV-2 has been isolated from samples from a pancreatic pseudocyst from a patient with acute pancreatitis [ 6 ]. SARS CoV-2 is particularly capable of causing severe diffuse endothelitis of submucosal vessels in several anatomical sites, and these changes that cause diffuse ischemia of certain organs [ 7 ] but to date the direct association between COVID-19 and acute pancreatitis is not based on evidence. During acute pancreatitis the pancreas will undergo alterations in its microcirculation in the form of vasoconstriction and progressive exclusion of capillaries resulting in a decrease in local vascularization promoting the appearance of necrosis which may be systemic due to the significant release of inflammatory mediators such as IL-1A and phospholipase A2 which induce global endothelial dysfunction and increase vascular permeability [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Total gastric necrosis following acute pancreatitis in a patient with COVID -19: Case report and literature review

Bouali

Ouchane

Elbakouri

et al. 2021

Annals of Medicine and Surgery

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“…Curiously, in a recent study published by Schepis et al, SARS-COV-2 RNA was detected in a pancreatic pseudocyst sample endorsing pancreatic involvement in COVID-19. 15 …”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 leading to acute pancreatitis: an unusual presentation

Alves

Yvamoto

Marzinotto

et al. 2020

The Brazilian Journal of Infectious Diseases

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During SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) pandemic, the etiologic agent of COVID-19, several studies described the involvement of other tissues besides the respiratory tract, such as the gastrointestinal tract. Angiotensin-converting enzyme-2, the functional virus host cell receptor expressed by organs and tissues, seems to have an important role in the pathophysiology and presentation of this disease. In pancreas, this receptor is expressed in both exocrine glands and islets, being a potential target for the virus and subsequent pancreatic injury. There are few articles reporting pancreatic injury in COVID-19 patients but most of them do not report acute pancreatitis. Diagnosing acute pancreatitis secondary to SARS-CoV-2 infection is challenging due to the need to rule out other etiologies as well the notable heterogeneous presentations. Herein we report the case of a patient with COVID-19 who developed severe acute pancreatitis.

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SARS-CoV2 RNA detection in a pancreatic pseudocyst sample

Cited by 71 publications

References 7 publications

Coronavirus disease 2019 and the pancreas

Coronavirus disease 2019 and the pancreas

Total gastric necrosis following acute pancreatitis in a patient with COVID -19: Case report and literature review

SARS-CoV-2 leading to acute pancreatitis: an unusual presentation

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