2020 DOI: 10.20944/preprints202009.0459.v1 View full text Preprint
Srilakshmi Chaparala, Carrie L Iwema, Ansuman Chattopadhyay

Abstract: The COVID-19 global pandemic has created dire consequences with an alarming rate of morbidity and mortality. There are not yet vaccine or efficacious treatment options to combat the causative SARS-CoV-2 infection. This paper describes the identification of potentially repurposable drugs for COVID-19 treatment by conducting pathway enrichment analysis on publicly available Gene Expression Omnibus datasets. We first determined SARS-CoV-2 infection-induced alterations of host gene expressions and pathways. We the…

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