SARS-CoV-2 infections among neonates born to women with SARS-CoV-2 infection: maternal, pregnancy and birth characteristics

Olsen, Emily O’Malley; Roth, Nicole; Aveni, Kathryn; Santos, Pauline; Sizemore, Lindsey; Halai, Umme-Aiman; Nestoridi, Eirini; Sowunmi, Similoluwa; Barton, Jerusha; Mobley, Evan; Siebman, Samantha; Fussman, Chris; Mbotha, Deborah; Dzimira, Paula; Silcox, Kristin; Khuwaja, Salma; Roscom, Danacamile; Lush, Mamie; Chicchelly, Sarah; Delgado-López, Camille; Schlosser, Levi; Read, Jennifer S.; Ellington, Sascha; Hall, Aron J.; Gilboa, Suzanne M.; Tong, Van T.; Woodworth, Kate R.

doi:10.21203/rs.3.rs-491688/v1

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Previous studies have demonstrated infants rooming in with mother encourages initiation of the infant being fed breastmilk, and rooming-in is recommended by numerous public health and clinical organizations to support breastfeeding [1,16,17,18,19]. While early recommendations included consideration for temporary separation of mothers with COVID-19 from their newborns, multiple studies have now found low incidence of SARS-CoV-2 infection among infants born to people with SARS-CoV-2 infection [20] and low risk of transmission from mother to infant when appropriate IPC is followed [21]. The AAP and CDC recommend that mothers with COVID-19 room-in with their infants and use appropriate IPC measures (e.g., masks, hand hygiene) even if asymptomatic [6,7].…”

Section: Discussionmentioning

confidence: 99%

Breast Milk Feeding of Infants at Birth Among People With Confirmed SARS-CoV-2 Infection in Pregnancy: SET-NET, 5 States, March 29, 2020–December 31, 2020

et al. 2022

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Objectives. To describe prevalence of breast milk feeding among people with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and examine associations between breast milk feeding, timing of maternal infection before delivery, and rooming-in status during delivery hospitalization. Methods. We performed a retrospective cohort study using data from Massachusetts, Minnesota, Nebraska, Pennsylvania, and Tennessee of whether people with confirmed SARS-CoV-2 infection during pregnancy in 2020 initiated breast milk feeding at birth. Results. Among 11 114 (weighted number) people with SARS-CoV-2 infection in pregnancy, 86.5% (95% confidence interval [CI] = 82.4%, 87.6%) initiated breast milk feeding during birth hospitalization. People with infection within 14 days before delivery had significantly lower prevalence of breast milk feeding (adjusted prevalence ratio [APR] = 0.88; 95% CI = 0.83, 0.94) than did those with infection at least 14 days before delivery. When stratified by rooming-in status, the association between timing of infection and breast milk feeding remained only among infants who did not room in with their mother (APR = 0.77; 95% CI = 0.68, 0.88). Conclusions. Pregnant and postpartum people with SARS-CoV-2 infection should have access to lactation support and be advised about the importance of breast milk feeding and how to safely feed their infants in the same room. (Am J Public Health. 2022;112(S8):S787–S796. https://doi.org/10.2105/AJPH.2022.307023 )

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Section: Discussionmentioning

confidence: 99%

Breast Milk Feeding of Infants at Birth Among People With Confirmed SARS-CoV-2 Infection in Pregnancy: SET-NET, 5 States, March 29, 2020–December 31, 2020

et al. 2022

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“…expansion and availability of COVID-19-related data, additional studies appeared reporting adverse perinatal outcomes associated with SARS-CoV-2 infection during pregnancy comprising an increased risk of maternal ICU admission, cesarean delivery, preterm birth, and congenital anomalies among other effects. [9][10][11][12] Meanwhile, early epidemiologic data from the pandemic revealed that African Americans, Native Americans, and Hispanics were disproportionately impacted by the pandemic, marked by elevated rates of SARS-CoV-2 infection and heightened risk of adverse COVID-19 related outcomes including mortality in these populations. [13][14][15][16] Over the past two decades similar racial and ethnic disparities have been observed in several pregnancyrelated outcomes.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Association between SARS-CoV-2 Infection and Adverse Perinatal Outcomes by Race/Ethnicity in a Large Integrated Health Care System

Mensah,

Fassett,

Lurvey

et al. 2024

Am J Perinatol

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Objective: Recent studies have reported associations between SARS-CoV-2 infection during pregnancy and adverse perinatal outcomes but the extent to which these associations vary by race/ethnicity remains uncertain. Therefore, we examined how the association between prenatal SARS-CoV-2 infection and adverse perinatal outcomes may be modified by race/ethnicity. Study Design: A retrospective cohort study was performed using data on 67,986 pregnant women extracted from the Kaiser Permanente Southern California electronic health records between 04/06/2020-12/31/2021. Upon admission to labor & delivery, all women were routinely tested for COVID-19 using RT-PCR test. Adjusted odds ratios (aOR) were used to estimate associations. Results: During the study period, COVID-19 was diagnosed in 4,960 (7%) of singleton pregnancies, with the highest rates observed among Hispanics (9.4%) and Non-Hispanic Blacks (6.2%). Compared with Non-Hispanic Whites, Hispanics (aOR:1.12, 95% CI: 1.03-1.21) with SARS-CoV-2 infection had the highest odds of a pregnancy associated with non-reassuring fetal heart rate tracing. Neonates of all races/ethnicities, except for non-Hispanic Blacks, showed significantly increased odds of SARS-CoV-2 infection, with the highest risk observed among Asians/Pacific Islanders (aOR:10.88, 95% CI: 1.33-89.04). Non-Hispanic White mothers who tested positive were admitted to ICU at a higher rate at delivery and within 7 days of delivery (aOR:34.77, 95% CI: 11.3-107.04; aOR:26.48, 95% CI: 9.55-73.46, respectively), Hispanics were also at a significantly higher odds of admission to ICU (aOR:4.62, 95% CI: 2.69-7.94; aOR:4.42, 95% CI: 2.58-7.56, respectively). Non-Hispanic Black, Hispanic and Asian mothers who tested positive for SARS-CoV-2 prenatally, were at increased risk for preeclampsia/eclampsia, and preterm birth as compared to Non-Hispanic White mothers. Conclusion: The findings highlight racial/ethnic disparities in the association between SARS-CoV-2 infection and adverse perinatal outcomes. The risk of neonatal SARS-CoV-2 infection was highest for Asian/Pacific Islanders. We also observed a remarkably high risk of ICU admission for non-Hispanic White mothers infected with SARS-CoV-2.

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Illness severity indicators in newborns by COVID-19 status in the United States, March–December 2020

et al. 2021

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SARS-CoV-2 infections among neonates born to women with SARS-CoV-2 infection: maternal, pregnancy and birth characteristics

Cited by 4 publications

References 7 publications

Breast Milk Feeding of Infants at Birth Among People With Confirmed SARS-CoV-2 Infection in Pregnancy: SET-NET, 5 States, March 29, 2020–December 31, 2020

Breast Milk Feeding of Infants at Birth Among People With Confirmed SARS-CoV-2 Infection in Pregnancy: SET-NET, 5 States, March 29, 2020–December 31, 2020

Association between SARS-CoV-2 Infection and Adverse Perinatal Outcomes by Race/Ethnicity in a Large Integrated Health Care System

Illness severity indicators in newborns by COVID-19 status in the United States, March–December 2020

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