SARS-COV-2 (Covid-19) and male fertility: Where are we?

Omolaoye, Temidayo S.; Adeniji, A. A.; Maya, Wálter Cardona; Plessis, Stefan S. du

doi:10.1016/j.reprotox.2020.11.012

Cited by 39 publications

(39 citation statements)

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“…A cohort study has assessed SARS-CoV-2 in human semen, and their findings suggested that semen parameters were altered after a moderate infection [7] . Similarly, a recent systematic review also demonstrated that potential male fertility issues might be induced by SARS-CoV-2 infection [21] , which was reinforced by many other studies [ 22 – 24 ]. However, in regard to females, most studies suggested that SARS-CoV-2 infection was unlikely to have a long-term adverse effect on female reproductive function [25] , according to our clinically observed results.…”

Section: Discussionmentioning

confidence: 66%

Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study

et al. 2021

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Background: The current study aimed to investigate the impact of asymptomatic or mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on female fertility and laboratory and clinical outcomes in assisted reproductive technology (ART) treatments. Methods: Patients undergoing ART treatments in the Reproductive Medicine Center, Tongji Hospital, Wuhan, from May 2020 to February 2021 were enrolled. Seventy of them were positive for serum SARS-CoV-2 antibodies (IgG and/or IgM), and 3973 patients had negative results. Propensity score matching with a ratio of 1:3 was performed, and there were 65 females in the case group and 195 females in the control group. Findings: The ovarian reserves and ovarian responses between groups after matching were similar. The proportions of mature oocytes, damaged oocytes, fertilized oocytes, cleavage embryos, high-quality embryos, and available blastocysts were also similar, despite a slight decrease in the blastocyst formation rate in the case group. In addition, there were no significant differences in terms of the biochemical pregnancy rate, clinical pregnancy rate, early miscarriage rate, or implantation rate. Interpretation: There is no evidence that a history of asymptomatic or mild SARS-CoV-2 infection in females may negatively affect female fertility, embryo laboratory outcomes, or clinical outcomes in ART treatments.

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Section: Discussionmentioning

confidence: 66%

Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study

et al. 2021

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“…Объективные затруднения в оказании своевременной специализированной помощи населению на фоне мобилизации резервов системы здравоохранения также могли оказать системное влияние на мужское репродуктивное здоровье [7]. В некоторых работах описано присутствие вирусных частиц в эякуляте, что, однако, не позволяет делать выводы о наличии специфических механизмов угнетения мужской фертильности на фоне COVID-19 [3]. Результаты аутопсии мужчин, умерших от новой коронавирусной инфекции, продемонстрировали выраженные изменения тестикулярной ткани [8].…”

Section: Discussionunclassified

“…Все чаще к андрологам обращаются пациенты, которые перенесли COVID-19, а в настоящее время стремятся к естественному зачатию. Мужчины со снижением фертильного потенциала после SARS-CoV-2-инфекции представляют собой новую, уникальную, многочисленную группу пациентов, в отношении которых еще не выработана рациональная тактика обследования и лечения [3].…”

Section: Introductionunclassified

Evaluating the effect of BESTFertil antioxidant complex on semen parameters and severity of asthenic syndrome in men with a recent history of novel coronavirus infection (COVID-19)

Shatylko

Гамидов²,

Popova³

2021

Androl. genit. hir.

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Introduction. Direct influence of novel coronavirus infection (COVID-19) on male fertility is still unproven. However, through prolonged fever, hypoxia, systemic inflammation and other yet incompletely described factors this disease may apparently cause not only “long COVID” syndrome, but also transitory non-specific impairment of spermatogenesis. The study objective is to evaluate the effectiveness of administration of Russian complex with unique composition BESTFertil in case of decreased fertility and asthenic syndrome in males after new coronavirus infection.Materials and methods. We performed a non-blinded randomized prospective controlled trial which included 60 male patients with a history of COVID-19 not earlier than 6 months prior to enrollment from couples planning to have children. Patients were included if they had pre-disease semen analysis results available. They were divided into two equal groups. Group 1 (main group) received BESTFertil complex for 12 weeks, while Group 2 (comparison group) received no additional treatment. At baseline and 12-week follow-up all patients underwent semen analysis, MAR test, sperm DNA fragmentation test, serum sex hormone profiling and completed the “Asthenic condition scale” questionnaire. Student's t-test, Wilcoxon test, Mann-Whitney U-test and McNemar test were used for statistical analysis.Results. When comparing retrospective and baseline values we found no critical influence of COVID-19 on semen parameters, though a moderate decrease of percentage of sperm with progressive motility could be observed (40.5 % vs 30 %, p = 0.008). Group 1 had a stronger tendency toward recovery of semen parameters. Patients receiving BESTFertil had median total motile sperm count increased from 48.5 million to 76.8 million (p = 0.032), while in comparison group it increased from 39.8 million to 49.2 million (p = 0.317). BESTFertil antioxidant complex had no negative influence on endocrine profile. Moreover, there was a statistically significant decrease of sperm DNA fragmentation index from 21.2 to 13.9 % (p = 0.007) in Group 1. Lower rate of asthenic symptoms was observed in Group 1 which received BESTFertil.Conclusion. Men with a recent history of COVID-19 had a moderate decrease of surrogate fertility markers, most probably due to non-specific mechanisms. Patients receiving BESTFertil had a more pronounced recovery of semen parameters and improvement in post-COVID asthenic syndrome.

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“… Chen et al, 2020a , Chen et al, 2020b , Chen et al, 2020c , Dong et al, 2020a , Dong et al, 2020b , Douglas et al, 2004 , Glowacka et al, 2011 , Green et al, 2018 , Grive et al, 2019 , Guo et al, 2018 , Guo et al, 2017 , Li et al, 2020a , Li et al, 2020b , Li et al, 2020c , Lukassen et al, 2018 , Muñoz et al, 2014 , Omolaoye et al, 2020 , , xxxx , WoldHealthOrganization, 2020 , Xu et al, 2006 .…”

Section: Uncited Referencesmentioning

confidence: 99%

Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system

Wang

Qin

et al. 2021

Stem Cell Research

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Since the emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in December 2019, it has rapidly spread across many countries and it has become a crucial global health concern. Furthermore, SARS-CoV-2 infection not only effect on respiratory system, but on reproductive system of human. However, there has been not any review described the transmission paths and effects of SARS-CoV-2 infection on human reproductive system, systematically. In order to describe the transmission paths of SARS-CoV-2, effect on the male/female reproductive system of SARS-CoV-2 and some successful prevention measures. We would like to review effect of SARS-CoV-2 on reproductive system. To conclude, SARS-CoV-2 infection might damage to male reproductive system via ACE2 receptor mediating and male patients were reportedly slightly more affected than women by SARS-CoV-2 infections .

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SARS-COV-2 (Covid-19) and male fertility: Where are we?

Cited by 39 publications

References 54 publications

Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study

Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study

Evaluating the effect of BESTFertil antioxidant complex on semen parameters and severity of asthenic syndrome in men with a recent history of novel coronavirus infection (COVID-19)

Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system

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