Sarkombildung durch Polyoma-Virus in der Niere von Ratten

Georgii, A.; Prechtel, K; H, Zobl

doi:10.1007/bf00524786

Cited by 12 publications

(3 citation statements)

References 8 publications

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“…Nevertheless, it has not been encountered very often, and the inclusion of this tumor in the STP papers has been based in part on experimental experience with renal sarcoma induced by systemic injection of polyoma virus into perinatal rats (Georgii, Prechtel, and Zobl 1969). Little is known about this tumor's biology, true identity, or distinguishing features separating it from RMT.…”

Section: Discussionmentioning

confidence: 98%

“…Renal sarcoma is included as an entity in the STP papers on standardized nomenclature in toxicologic pathology (Hard et al 1995) and in the most recent INHAND document on proliferative and nonproliferative lesions of the rat kidney (Frazier et al 2012). Nevertheless, it has not been encountered very often, and the inclusion of this tumor in the STP papers has been based in part on experimental experience with renal sarcoma induced by systemic injection of polyoma virus into perinatal rats (Georgii, Prechtel, and Zobl 1969). Little is known about this tumor’s biology, true identity, or distinguishing features separating it from RMT.…”

Section: Discussionmentioning

confidence: 99%

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A Survey of Mesenchyme-related Tumors of the Rat Kidney in the National Toxicology Program Archives, with Particular Reference to Renal Mesenchymal Tumor

2016

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In order to harmonize diagnostic terminology, confirm diagnostic criteria, and describe aspects of tumor biology characteristic of different tumor types, a total of 165 cases of mesenchyme-related tumors and nephroblastomas of the rat kidney were reexamined from the National Toxicology Program (NTP) Archives. This survey demonstrated that renal mesenchymal tumor (RMT) was the most common spontaneous nonepithelial tumor in the rat kidney, also occurring more frequently in the NTP studies than nephroblastoma. Renal sarcoma was a distinct but very rare tumor entity, representing a malignant, monomorphous population of densely crowded, fibroblast-like cells, in which, unlike RMT, preexisting tubules did not persist. Nephroblastoma was characterized by early death of affected animals, suggesting an embryonal origin for this tumor type. Male and female rats were equally disposed to developing RMT, but most of the cases of nephroblastoma occurred in female rats and liposarcoma occurred mostly in male rats. This survey confirmed discrete histopathological and biological differences between the mesenchyme-related renal tumor types and between RMT and nephroblastoma. Statistical analysis also demonstrated a lack of any relationship of these renal tumor types to test article administration in the NTP data bank.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A Survey of Mesenchyme-related Tumors of the Rat Kidney in the National Toxicology Program Archives, with Particular Reference to Renal Mesenchymal Tumor

2016

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“…In several studies by Prechtel et al, the carcinogenic effect of poliovirus for the kidney of Wistar Lewis rats was demonstrated [60,65]. In these German studies, rats developed quasi-essentially kidney sarcomas with the number, by kidney, size, growth speed, and frequency, directly correlating to the importance of the viral inoculum [60,65].…”

Section: Viro-induced Ccrcc Animal Modelsmentioning

confidence: 99%

Heading Towards a Possible Rebirth of the Induced Renal Cell Carcinoma Models?

Mazzola¹,

Ribatti

2020

Cancers

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Introduction: Animal models are interesting tools to improve our knowledge of the pathophysiological processes underlying kidney cancer development. Recent advances have been made in the understanding of the genetic founding events underlying clear cell renal carcinoma. The aim of this paper was to review and discuss the characteristics of all the induced animal models of renal carcinogenesis that have been described in the scientific literature to date and to see if and how they could regain some use in the light of the latest discoveries. Methods: The authors reviewed all the papers available in PubMed regarding induced animal models of renal carcinogenesis. From this perspective, the keywords “induced”, “animal model”, and “renal cancer” were used in PubMed’s search engine. Another search was done using the keywords “induced”, “animal model”, and “kidney cancer”. PRISMA recommendations were used to develop the literature review. Results: Seventy-eight studies were included in this review. Results were presented depending on the mechanisms used to induce carcinogenesis in each model: induction by carcinogens, hormones, viral induction, or induction by other agents. Discussion focused on the possibility to rethink these different induced animal models and use them to answer new research questions. Conclusion: Many induced animal models have been developed in the past to study renal cancer. While these models seemed unable to yield new knowledge, the latest advances in the understanding of the genetics behind renal carcinogenesis could well bring the models back to the forefront.

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Renal Carcinogenesis, Rat

Hard¹

1998

Urinary System

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Sarkombildung durch Polyoma-Virus in der Niere von Ratten

Cited by 12 publications

References 8 publications

A Survey of Mesenchyme-related Tumors of the Rat Kidney in the National Toxicology Program Archives, with Particular Reference to Renal Mesenchymal Tumor

A Survey of Mesenchyme-related Tumors of the Rat Kidney in the National Toxicology Program Archives, with Particular Reference to Renal Mesenchymal Tumor

Heading Towards a Possible Rebirth of the Induced Renal Cell Carcinoma Models?

Renal Carcinogenesis, Rat

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