Sarkoma Ewing

Gozal, Fenny; Djakaria, H.M

doi:10.32532/jori.v8i1.58

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…It has been found that treating some types of cancer with chemotherapy or radiation when combined with heat therapy is much more effective than by conventional cancer therapies alone [17][18][19][20]. The research conducted by Gozal and Djakaria [21] has shown promising results in the treatment of Ewing Sarcoma which is the second most common bone tumor, predominantly affecting individuals in the age range of 10 to 30 years. Through a combination of chemotherapy and thermotherapy, they increased the 5-year survival rate for patients from less than 10% to more than 60%.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of heat transfer in tissues with skin tumor during thermotherapy

Sherief,

Zaky,

Abbas

et al. 2024

PLoS ONE

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The study of thermal therapy to tumors and the response of living cells to this therapy used to treat tumor is very important due to the complexity of heat transfer in biological tissues. In the past few years, there has been a growing interest among clinicians, mathematicians, and engineers regarding the use of computational and mathematical methods to simulate biological systems. Numerous medical proceedings also employ mathematical modeling and engineering techniques as a means to guarantee their safety and evaluate the associated risks effectively. This manuscript provides an analytical solution used for the first time to study the mechanism of biological thermal response during heat therapy on spheroidal skin tumor. The proposed method used a generalized thermoelasticity model with one relaxation time. The influence of relaxation times on the responses of diseased and healthy tissues is studied and interpreted graphically. Also, the impact of different laser irradiance on the thermal profile of the malignant tumor cells over a period of 2 minutes is interpreted graphically. To investigate the transfer of heat within biological tissues during the thermal therapy, the Laplace transform and inverse Laplace transform methods were applied. A comparison of the present generalized thermoelasticity model and different models based on Pennes bioheat transfer PBT shows that our proposed model yields more realistic and accurate predictions. The current model can be used to explain various therapeutic methods.

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Section: Introductionmentioning

confidence: 99%

Mathematical modeling of heat transfer in tissues with skin tumor during thermotherapy

Sherief,

Zaky,

Abbas

et al. 2024

PLoS ONE

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“…One of the locations of the ewing sarcoma tumor is in the bone in the lower arm (forearm). According to Gozal and Djakaria [10], using a combination of chemotherapy treatments, surgery, and treatment using radiotherapy or increased temperature in tumors, it can reduce the 5-year survival rate from <10% to >60% in patients with Ewing Sarkoma Tumor.…”

Section: Introductionmentioning

confidence: 99%

Effect of Blood Perfusion on Temperature Distribution in the Multilayer of the Human Body with Interstitial Hyperthermia Treatment for Tumour Therapy

Wahyudi

Vardiansyah

Setyorini

2022

CFDL

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Blood perfusion is defined as the volume of blood flowing through units of tissue volume per second. In thermoregulation, blood perfusion is a factor that affects heat transfer in the body, the greater the rate of blood perfusion will complicate the distribution of temperature throughout the body. In the study of bioheat transfer, heat transfer in the human body can be used as a therapy. At therapeutic temperatures (above 40°C), cells will die and stop their growth or commonly called hyperthermia therapy. It can allow thermonecrosis in body tissues and can be useful for tumour tissue. Of the various types of hyperthermia therapy, interstitial hyperthermia therapy is considered more effective because heat is directly delivered to tumour tissue to minimize other tissues exposed to therapeutic temperatures. Currently, there are no studies that study the effect of blood perfusion on the treatment of interstitial hyperthermia, even though blood perfusion greatly affects the temperature distribution in the human body/ In this study, heat transfer analysis will be performed on five layers of the human body, namely the epidermis, dermis, fat, muscle, and bones with interstitial application of hyperthermia therapy and affected by blood perfusion with a value of (8x10-4; 4x10-4; 2x10-4; 1x10-3; and 2x10-3)/s completed using finite element method with unsteady conditions in two axial dimensions. The part of the tumour studied is a tumour in the arm (forearm) in the span of 600s. This study shows that blood perfusion affects the value of temperature distribution in five layers of the body in unsteady conditions. The greater the value of blood perfusion flowing in the body, the more difficult the temperature will be to transmit because the blood distributes heat throughout the body faster, the difference between blood perfusion values is quite significant.

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Sarkoma Ewing

Cited by 2 publications

References 23 publications

Mathematical modeling of heat transfer in tissues with skin tumor during thermotherapy

Mathematical modeling of heat transfer in tissues with skin tumor during thermotherapy

Effect of Blood Perfusion on Temperature Distribution in the Multilayer of the Human Body with Interstitial Hyperthermia Treatment for Tumour Therapy

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