Sarcopenia is common in adults with complex congenital heart disease

Sandberg, Camilla; Johansson, Karna; Christersson, Christina; Hlebowicz, Joanna; Thilén, Ulf; Johansson, Bengt

doi:10.1016/j.ijcard.2019.06.011

Cited by 40 publications

(38 citation statements)

References 27 publications

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“…This could indicate that decline in muscle mass occurs slower than muscle strength and becomes visible first in adulthood. In contrast to our results on lean mass, there are previous reports on reduced lean mass in adults 1,15 as well as in children with Fontan circulation. 16 Taken together, this stresses the need of future research regarding underlying mechanisms and development of muscle strength and lean mass over time.…”

Section: Discussioncontrasting

confidence: 99%

“…The present results regarding the impaired muscle strength in adolescents with Fontan circulation comply with the impaired isometric knee extension muscle strength recently reported in adults with different complex heart lesions 15 and previous data on impaired grip strength and respiratory muscle strength in adults with CHD. [1][2][3] It is currently not known if this impairment is already present in early childhood, or if it develops with age.…”

Section: Discussionsupporting

confidence: 92%

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Impaired knee extension muscle strength in adolescents but not in children with Fontan circulation

et al. 2020

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Abstract Introduction: Impaired isometric muscle strength was previously reported in adults with Fontan circulation. However, it is unclear if this impairment is present in children and adolescents with Fontan circulation. We investigated isometric muscle strength of the lower limb in patients (6–18 years) with Fontan circulation in comparison with healthy controls. Method: In this cross-sectional study, 43 patients (6–18 years) with Fontan circulation and 43 age- and sex-matched controls were included. Isometric knee extension and plantar flexion muscle strength were assessed using dynamometry (Newton, N). Lean mass of the legs was assessed with dual-energy X-ray absorptiometry. Analyses were performed on group level (n = 43), and for subgroups that included children aged 6–12 years (n = 18) and adolescents aged 13–18 years (n = 25). Results: On group level, the patients with Fontan circulation had impaired isometric knee extension strength in comparison with the controls (p = 0.03). In subgroup analyses, impaired isometric knee extension strength was present in the adolescents (p = 0.009) but not in the children groups. For plantar flexion, there was no difference between patients and controls. There was no difference in lean mass between patients and controls (9.6 ± 4.3 kg vs. 10.8 ± 5.6 kg, p = 0.31). However, the lean mass was highly correlated to isometric knee extension strength (patients r = 0.89, controls r = 0.96, p < 0.001) and isometric plantar flexion strength (patients r = 0.7, controls r = 0.81, p < 0.001). Conclusion: The finding of impaired isometric knee extension muscle strength in adolescents (13–18 years) with Fontan circulation and no corresponding impairment in the children group (6–12 years) could imply that isometric muscle strength gets more impaired with age.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Impaired knee extension muscle strength in adolescents but not in children with Fontan circulation

et al. 2020

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“…In 2018, the revised European criteria for sarcopenia (EWGSOP-2) were published, where the leading role was given to muscle strength, taking into account its greater clinical, social and prognostic significance. The following diagnosis algorithm is recommended [8]: verification of decreased muscle strength, verification of reduced muscle mass or quality, assessment of muscle performance. Reduced muscle strength is a prerequisite for the updated EWGSOP-2 criteria.…”

Section: Introductionmentioning

confidence: 99%

Cystatin C level as a prognostic risk factor for postoperative complications in elderly patients

Rasenko¹

2020

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. An important criterion for assessing the course of urgent surgical pathology in elderly patients is the concomitant state of sarcopenia. Decreased blood levels of cystatin C, which correlates with decreased muscle mass and strength, is an important screening criterion for perioperative intensive care therapy in these patients. The aim of the study was to increase the effectiveness of intensive care in patients with low sarcopenic index by improving the methods of influencing perioperative risk factors. We examined 90 elderly patients (73.3±7.9 years) with surgical pathology of the abdominal cavity, who underwent emergency surgery under general anesthesia based on sodium thiopental with artificial lung ventilation. Patients were divided into 3 randomized groups by age, sex, anthropometric data, volume and duration of surgery, concomitant comorbid background and perioperative intensive care: group I (n=30) – patients undergoing standard intensive perioperative therapy, group II (n=30) – standard intensive care with the addition of levocarnitine; group III (n=30) – standard intensive care with the addition of levocarnitine and a solution of D-fructose-1,6-diphosphate sodium salt hydrate. Muscle mass was determined by bioimpedancemetry on the analyzer “MEDASS” ABC-02, muscle strength was assessed by wrist dynamometry, muscle-skeletal mass index was calculated. The serum cystatin C concentration was determined by latex-enhanced immunoturbidimetry (DIALAB GmbH, Austria). The significance of the obtained data was checked using the r-Pearson correlation coefficient. It is established that additional prescription of levocarnitine and D-fructose-1,6-diphosphate sodium hydrate salt significantly reduces the number of days of treatment in the intensive care unit, improves prognosis, and promotes early activation of patients. Metabolic changes caused by a decreased sarcopenic index require further research.

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“…This phenomenon occurs not only in elderly people but also in patients with chronic illnesses such as, chronic heart failure (HF), liver dysfunction, and kidney dysfunction [1-5], which is called secondary sarcopenia. Possible explanations for sarcopenia include an abnormal energy metabolism coupled with mitochondrial dysfunction as well as a change in the structure of the myofibers, malnutrition, systemic inflammation, and oxidative stress [6][7][8][9].Recent studies have reported that secondary sarcopenia is not rare in adults with congenital heart disease (CHD) [10,11]. Sarcopenia is one of the important predictors of HF in non-CHD [12][13][14]; whereas, it remains unclear whether sarcopenia is also relevant to prognosis in adults with CHD.…”

mentioning

confidence: 99%

“…Recent studies have reported that secondary sarcopenia is not rare in adults with congenital heart disease (CHD) [10,11]. Sarcopenia is one of the important predictors of HF in non-CHD [12][13][14]; whereas, it remains unclear whether sarcopenia is also relevant to prognosis in adults with CHD.…”

mentioning

confidence: 99%

Secondary sarcopenia assessed by computed tomography can predict hospitalization for heart failure in adults with Fontan circulation

Shiina

Nagao

Shimomiya

et al. 2021

Journal of Cardiology

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Sarcopenia is a loss of muscle mass and function [1]. This phenomenon occurs not only in elderly people but also in patients with chronic illnesses such as, chronic heart failure (HF), liver dysfunction, and kidney dysfunction [1-5], which is called secondary sarcopenia. Possible explanations for sarcopenia include an abnormal energy metabolism coupled with mitochondrial dysfunction as well as a change in the structure of the myofibers, malnutrition, systemic inflammation, and oxidative stress [6][7][8][9].Recent studies have reported that secondary sarcopenia is not rare in adults with congenital heart disease (CHD) [10,11]. Sarcopenia is one of the important predictors of HF in non-CHD [12][13][14]; whereas, it remains unclear whether sarcopenia is also relevant to prognosis in adults with CHD. In particular, skeletal muscle function is important in Fontan circulation because a passive blood flow in a Fontan route can be maintained by both skeletal muscle pumping and the change of intrapleural pressure (ventilatory pumping) [15][16][17]. However, it is challenging to measure the entire skeletal muscle mass; until now, dual energy X-ray absorptiometry or bioelectrical impedance analysis (BIA) has been used to measure it [1,2]. The former method needs special equipment, and the latter is not available to patients after pacemaker implantation. The biggest issue in adults with Fontan circulation is that most patients have already undergone pacemaker implantation; therefore,

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Sarcopenia is common in adults with complex congenital heart disease

Cited by 40 publications

References 27 publications

Impaired knee extension muscle strength in adolescents but not in children with Fontan circulation

Impaired knee extension muscle strength in adolescents but not in children with Fontan circulation

Cystatin C level as a prognostic risk factor for postoperative complications in elderly patients

Secondary sarcopenia assessed by computed tomography can predict hospitalization for heart failure in adults with Fontan circulation

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