Sarcopenia, but not excess weight or increased caloric intake, is associated with coronary subclinical atherosclerosis in the very elderly

Campos, André; Moura, Filipe A.; Santos, Simone N.; Freitas, Wladimir M.; Sposito, Andrei C.

doi:10.1016/j.atherosclerosis.2017.01.005

Cited by 57 publications

(44 citation statements)

References 42 publications

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“…Studies have also shown that skeletal muscle mass can affect carotid intima thickness 37,38 and is closely related to the occurrence of subclinical atherosclerosis. [39][40][41][42] The present study suggested that both metabolic syndrome components and muscle mass loss play an important role in carotid atherosclerosis. Binary logistic regression analysis showed that SBP and presarcopenia were both independent risk factors for carotid atherosclerosis.…”

Section: Discussionsupporting

confidence: 49%

<p>Presarcopenia Is an Independent Risk Factor for Carotid Atherosclerosis in Chinese Population with Metabolic Syndrome</p>

Cao¹,

Zhong²,

Zhang

et al. 2020

DMSO

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Purpose: To investigate the impacts of skeletal muscle mass on carotid atherosclerosis in Chinese adults with metabolic syndrome (MetS). Methods: One hundred and ninety-five subjects with MetS had the waist-to-height ratio (WHTR)≥0.5 for all. One hundred and eighty-four subjects without MetS were divided into 2 groups: Non-Mets obese group (WHTR ≥ 0.5, n = 118) and Non-MetS control group (WHTR < 0.5, n = 66). All the groups had no difference in age. Appendicular skeletal muscle mass was acquired and skeletal muscle mass index (SMI) was calculated. Carotid intima-media thickness (IMT) was assessed by ultrasonography. Each group was stratified according to the presence or absence of presarcopenia. Results: While most parameters showed an increasing trend with WHTR and MetS in both genders, SMI and HDL-C showed a decreasing trend. The prevalence of carotid atherosclerosis showed the same increasing trend. Multivariate logistic regression analyses showed SBP and presarcopenia were both independent risk factors for carotid atherosclerosis in MetS (OR 1.026, P < 0.001; OR 2.788, P = 0.001, respectively). There was no significant difference in IMT among the three groups with preserved muscle mass whether the participants suffered from obesity or MetS, while there was a significant difference between the two groups with presarcopenia (in male P = 0.020, in female P = 0.009, respectively). The area under the ROC curve (AUC) was 0.641 (P<0.001) for presarcopenia. Conclusion: Obesity was a risk factor for sarcopenia independent of age, especially in subjects with metabolic syndrome. In individuals with MetS, our findings suggest that presarcopenia may be an independent risk factor for atherosclerosis and appendicular skeletal muscle mass had potential protective effects for carotid atherosclerosis regardless of gender.

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Section: Discussionsupporting

confidence: 49%

<p>Presarcopenia Is an Independent Risk Factor for Carotid Atherosclerosis in Chinese Population with Metabolic Syndrome</p>

Cao¹,

Zhong²,

Zhang

et al. 2020

DMSO

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“…27 Participants with the lowest tertile of flow-mediated dilation had a higher risk of sarcopenia defined by skeletal muscle mass index (odds ratio 5.44, 95% CI 1.22-24.24). 27 Hence hypertension-induced endothelial dysfunction might exacerbate muscle wasting. Therefore, in nonhypertensive participants, age-related endothelial dysfunction might induce atherosclerosis and, in turn, exacerbate muscle wasting.…”

Section: Discussionmentioning

confidence: 95%

“…Hypertension is a well known risk factor for endothelial impairment . Although endothelial impairment, as evidenced by reduced flow‐mediated dilation, has been associated with skeletal muscle mass measured by dual‐energy X‐ray absorptiometry in Brazilian older people . Participants with the lowest tertile of flow‐mediated dilation had a higher risk of sarcopenia defined by skeletal muscle mass index (odds ratio 5.44, 95% CI 1.22–24.24) .…”

Section: Discussionmentioning

confidence: 99%

Association between atherosclerosis and handgrip strength in non‐hypertensive populations in India and Japan

Yamanashi

Kulkarni

Edwards

et al. 2018

Geriatrics Gerontology Int

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AimAlthough several risk factors contribute to the development of sarcopenia, whether preclinical atherosclerosis contributes to the risk of sarcopenia is not established. The present cross‐sectional study aimed to investigate if there is an association between preclinical atherosclerosis and muscle strength among two ethnic populations.MethodsParticipants included individuals aged ≥40 years and enrolled in the third follow‐up examination of the Andhra Pradesh Children and Parents Study, India, and in the baseline assessments of the Nagasaki Islands Study, Japan. Preclinical atherosclerosis was evaluated by carotid intima‐media thickness, brachial‐ankle pulse wave velocity, cardio‐ankle vascular index. The association of carotid intima‐media thickness and pulse wave velocity/cardio‐ankle vascular index with handgrip strength (HGS) was analyzed separately in the sexes and for hypertensive status from the two cohorts using a multivariable linear regression model.ResultsData on a total of 1501 participants in India and 3136 participants in Japan were analyzed. Carotid intima‐media thickness was negatively associated with HGS in non‐hypertensive Indian men (B coefficient = −5.38, P = 0.036). Arterial stiffness was also associated with HGS in non‐hypertensive Indian men (B = −0.97, P = 0.001), but not in hypertensive Indian men. Same as Indian men, we found the significant associations between arterial stiffness and HGS in non‐hypertensive women in both India and Japan (B = −0.44, P = 0.020, B = −0.63, P = 0.016, respectively), but not in hypertensive women.ConclusionsThe negative association between preclinical atherosclerosis and HGS was dominantly found in non‐hypertensive participants. Geriatr Gerontol Int 2018; 18: 1071–1078.

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“…Indeed, Campos et al demonstrated that sarcopenia was associated with a 3.6-fold increase of subclinical atherosclerotic burden defined by coronary calcium score. 21 Moreover, endothelial dysfunction may be a possible pathophysiologic mechanism connecting sarcopenia to cardiovascular disease independent of other well-known cardiovascular risk factors. 22 Besides such clinical correlation between endothelial dysfunction and sarcopenia, many studies have reported molecular biological mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women

Yoo

Kim

et al. 2018

J cachexia sarcopenia muscle

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BackgroundThe aim of this study is to determine whether there is correlation between endothelial function and skeletal muscle function measured by hand grip strength in elderly women.MethodsThis cross‐sectional study used data of NAMGARAM‐2 cohort. The NAMGARAM‐2 cohort consisted of a group of people living in three rural communities. They were enrolled for studies on activity limitation due to age‐related musculoskeletal disorders including knee osteoarthritis, osteoporosis, and sarcopenia. They were residents aged 40 years or older. They agreed to participate in this cohort from March 2016 to May 2017. Peripheral endothelial function was assessed by reactive hyperaemia‐peripheral arterial tonometry using EndoPAT2000 system. Hand grip strength was measured using a digital hand dynamometer.ResultsEndothelial function index assessed by EndoPAT was worse in the low grip strength group than that in the normal group of elderly women (1.54 ± 0.51 in the low grip strength group vs. 1.77 ± 0.67 in the normal group, P = 0.003). There was a positive correlation between hand grip strength and endothelial function (r = 0.176, P = 0.007). On stepwise multivariate analysis, endothelial dysfunction (reactive hyperaemia‐peripheral arterial tonometry index < 1.67) significantly increased the risk of low hand grip strength (odds ratio = 2.019; 95% confidence interval = 1.107–3.682; P = 0.022).ConclusionsEndothelial function and skeletal muscle strength had a significant correlation in elderly women, providing additional support for the relevant role of vascular system in sarcopenia.

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Sarcopenia, but not excess weight or increased caloric intake, is associated with coronary subclinical atherosclerosis in the very elderly

Cited by 57 publications

References 42 publications

<p>Presarcopenia Is an Independent Risk Factor for Carotid Atherosclerosis in Chinese Population with Metabolic Syndrome</p>

<p>Presarcopenia Is an Independent Risk Factor for Carotid Atherosclerosis in Chinese Population with Metabolic Syndrome</p>

Association between atherosclerosis and handgrip strength in non‐hypertensive populations in India and Japan

Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women

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