Sarcopenia and nervous system disorders

Yang, Jie; Jiang, Feifei; Yang, Ming; Chen, Zhizhi

doi:10.1007/s00415-022-11268-8

Cited by 25 publications

(25 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A low BMI was an independent risk factor for seizures after LT. Low BMI was considered an indicator of sarcopenia in our LT population, which has been shown to be related to neurological disorders such as dementia, ischemic stroke, depression, and cognitive impairment in recent studies [ 28 ]. Dopaminergic dysfunction, neuronal hypoexcitability, brain atrophy, and neuromuscular junction dysfunction are the regulatory processes associated with the pathophysiology of sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study

Kang,

Koh,

Kim

et al. 2024

Transpl Int

View full text Add to dashboard Cite

Seizures are a frequent neurological consequence following liver transplantation (LT), however, research on their clinical impact and risk factors is lacking. Using a nested case-control design, patients diagnosed with seizures (seizure group) within 1-year post-transplantation were matched to controls who had not experienced seizures until the corresponding time points at a 1:5 ratio to perform survival and risk factor analyses. Seizures developed in 61 of 1,243 patients (4.9%) at median of 11 days after LT. Five-year graft survival was significantly lower in the seizure group than in the controls (50.6% vs. 78.2%, respectively, p < 0.001) and seizure was a significant risk factor for graft loss after adjusting for variables (HR 2.04, 95% CI 1.24–3.33). In multivariable logistic regression, body mass index <23 kg/m2, donor age ≥45 years, intraoperative continuous renal replacement therapy and delta sodium level ≥4 mmol/L emerged as independent risk factors for post-LT seizure. Delta sodium level ≥4 mmol/L was associated with seizures, regardless of the severity of preoperative hyponatremia. Identifying and controlling those risk factors are required to prevent post-LT seizures which could result in worse graft outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study

Kang,

Koh,

Kim

et al. 2024

Transpl Int

View full text Add to dashboard Cite

show abstract

“…In a meta-analysis of studies published in 2022, the occurrence of sarcopenia ranged from 10% to 27%, with the occurrence of severe sarcopenia falling within a range of 2%-9% (Petermann-Rocha et al, 2022). Both primary sarcopenia associated with aging as well as secondary sarcopenia resulting from other medical conditions, including neurological disorders, typically begin to occur in middle age and progress thereafter Yang et al, 2022). Evidence suggests that sarcopenia can co-occur in various neurological diseases, such as Parkinson's disease, multiple sclerosis, stroke, dementia, and myasthenia gravis (Cai et al, 2021;Cho et al, 2022;Ryan et al, 2017;Yang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…However, research regarding the relationship between sarcopenia and epilepsy is lacking. Dysfunction in mitochondria, neuromuscular signaling, endocrine factors, and inflammation play a significant role in the development of sarcopenia, which is more common in patients with epilepsy than in healthy individuals (Bakhtadze et al., 2021; Cruz‐Jentoft & Sayer, 2019; McNamara et al., 2017; Waldbaum & Patel, 2010; Yang et al., 2022). In addition, sleep disturbance is prevalent among patients with epilepsy, which is also considered one of the contributing factors to sarcopenia (Koike et al., 2023; Smith et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia and anti‐seizure medication response in juvenile myoclonic epilepsy

Kim,

Lee,

Lee

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

IntroductionThis study aimed to investigate the presence of sarcopenia in patients with juvenile myoclonic epilepsy (JME) and the association between sarcopenia and response to anti‐seizure medication (ASM) in patients with JME.MethodsWe enrolled 42 patients with JME and 42 healthy controls who underwent brain magnetic resonance imaging with three‐dimensional T1‐weighted imaging. We measured the temporal muscle thickness (TMT), a radiographic marker for sarcopenia, using T1‐weighted imaging. We compared the TMT between patients with JME and healthy controls and analyzed it according to the ASM response in patients with JME. We also performed a receiver operating characteristic (ROC) curve analysis to evaluate how well the TMT differentiated the groups.ResultsThe TMT in patients with JME did not differ from that in healthy controls (9.630 vs. 9.956 mm, p = .306); however, ASM poor responders had a lower TMT than ASM good responders (9.109 vs. 10.104 mm, p = .023). ROC curve analysis revealed that the TMT exhibited a poor performance in differentiating patients with JME from healthy controls, with an area under the ROC curve of .570 (p = .270), but good performance in differentiating between ASM good and poor responders, with an area under the ROC curve of .700 (p = .015).ConclusionThe TMT did not differ between patients with JME and healthy controls; however, it was reduced in ASM poor responders compared to ASM good responders, suggesting a link between ASM response and sarcopenia in patients with JME. TMT can be used to investigate sarcopenia in various neurological disorders.

show abstract

“…Sarcopenia is also associated with many diseases other than the musculoskeletal system. These can be either acute or chronic, and affect millions of people all over the world [5][6][7]. Overall, it results in an inability to perform daily tasks, dependence on the care of others, and an increased morbidity and mortality rate [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

Erkan,

OZCAN,

BEKIRCAVUSOGLU

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose Sarcopenia is the presence of low skeletal muscle quantity or quality. It is associated with increased morbidity and mortality. Aortic arch calcification (AAC) is a type of vascular calcification that can be easily detected using chest X-rays. AAC and sarcopenia share common risk factors such as aging, inflammation, diabetes mellitus, and chronic kidney disease. In this study, we investigated the relationship between AAC and sarcopenia to evaluate whether chest X-rays can be used to predict sarcopenia in daily clinical practice. Methods AAC was assessed via a simple chest X-ray. Sarcopenia was evaluated using chest computed tomography imaging, which allows for the calculation of skeletal mass area (SMA) and skeletal mass index (SMI). Correlation analysis and multivariable models were used to assess the relationship between AAC and sarcopenia. Results A total of 340 patients were included in this study (122 with AAC, and 218 without AAC). Sarcopenia was more frequent in patients with AAC than those without (38.5% vs 16.5%, p < 0.001). SMI was also negatively correlated with the severity of AAC (r: -0.246, p < 0.001). In the multivariable model, AAC was independently related to age, glomerular filtration rate, and sarcopenia [(OR = 1.077, 95% CI 1.034–1.120, p < 0.001), (OR = 0.985, 95% CI 0.975–0.996, p = 0.008), and (OR = 1.812, 95% CI 1.030–3.188, p = 0.03), respectively)]. Conclusion AAC detected by simple chest X-rays is independently related to sarcopenia. It might be used to predict patients with sarcopenia in this population.

show abstract

Sarcopenia and nervous system disorders

Cited by 25 publications

References 120 publications

Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study

Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study

Sarcopenia and anti‐seizure medication response in juvenile myoclonic epilepsy

Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

Contact Info

Product

Resources

About