Sarcoidosis associated with mycosis fungoides

Abstract

In November 1966, a 47-year-old black woman had a skin eruption and an abnormal chest roentgenogram that were found to be due to sarcoidosis. In September 1974, nodular lesions and subsequently generalized exfoliative dermatitis developed that were found to be due to mycosis fungoides. The concurrence of sarcoidosis and mycosis fungoides has been recorded only once in the literature. The depression of cell-mediated immunity found in this patient and other sarcoid patients suggests that impairment of the host's immunosurveillance system may predispose to the development of T-cell lymphomas.

Systemic sarcoidosis and cutaneous lymphoma: is the association fortuitous?

“…He suggested a non‐random, causal association between sarcoidosis and lymphoproliferative disease. The association of sarcoidosis and cutaneous lymphoma has only occasionally been reported 1–3 , 7…”

“…Simultaneous occurrence of systemic sarcoidosis and mycosis fungoides (MF) in the same patient has only rarely been observed 1–4 . A number of reports on extracutaneous malignant lymphoproliferative disorders in patients with systemic sarcoidosis may suggest, however, that this association is not fortuitous.…”

Sarcoidosis and cutaneous lymphoma: What is the relationship?

“…Several case reports describing concurrence of MF and sarcoidosis disease have been issued. 3 , 4 This diagnosis is complicated because sarcoidal tissue reactions associated with cutaneous T cell lymphomas can occur, and some types of MF or anaplastic large cell CD30 lymphoma can resemble sarcoid granulomas clinically and histologically. 2 , 5 Gelfand et al 5 reported a case similar to ours: a patient with systemic sarcoidosis that presented at diagnosis with self-resolving papulo-nodular necrotic lesions.…”

Granulomatous mycosis fungoides. Report of two cases and review of the literature

“…Granuloma formation concomitant with various malignant lymphomas and other malignant diseases [1][2][3][4] has been described. So far, the aetiology, pathogenesis and significance of this rare phenomenon have not been clarified.…”