Phytochem. Anal.
 1998
DOI: 10.1002/(sici)1099-1565(199811/12)9:6<296::aid-pca421>3.0.co;2-m
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Santonin: a new method of extraction from, and quantitative determination inArtemisia caerulescens ssp.cretacea (fiori) br.-catt. & gubell. by high-performance liquid chromatography

Elisabetta Miraldi
1
,
Sara Ferri
2
,
Gian Gabriele Franchi
3

Abstract: Santonin, a sesquiterpene lactone characteristic of many species of the genus Artemisia, has hitherto been quantitatively determined by long and complicated gravimetric procedures. A new, rapid, simple and accurate extraction and analytical procedure has been established. This high‐performance liquid chromatographic method employs a Licrospher 100‐RP column and a mobile phase consisting of acetonitrile:water in a gradient programme. Copyright © 1998 John Wiley & Sons, Ltd.

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Cited by 13 publications

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“…A HPLC method for the analysis of santonin was devised using parameters interpreted from previous publications [ 5 , 14 ]. The standard of santonin was run in the HPLC machine using a C18 column showing a retention time of approximately 5.7 minutes ( Fig 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…As it is known that the major compound santonin has potential toxicity [ 5 , 6 , 7 , 8 ] it is of interest to be able to quantify this compound in plants from the Artemisia genus or from any other plants that could contain santonin. The development of this HPLC method was based on previous papers and studies on santonin and sesquiterpene lactones as there has been little research carried out with A .…”
Section: Discussionmentioning
confidence: 99%
“…If the collection of these plants is not standardized then the results obtained may not give a true value or the desired outcome. In the case of santonin, the content is at a maximum when the flowering dried tops of the plants are collected at full bloom [ 5 ], also an important factor to be considered when preparing any effective veterinary medicine with minimum toxic effects.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…A HPLC method for the analysis of santonin was devised using parameters interpreted from previous publications [ 5 , 14 ]. The standard of santonin was run in the HPLC machine using a C18 column showing a retention time of approximately 5.7 minutes ( Fig 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…As it is known that the major compound santonin has potential toxicity [ 5 , 6 , 7 , 8 ] it is of interest to be able to quantify this compound in plants from the Artemisia genus or from any other plants that could contain santonin. The development of this HPLC method was based on previous papers and studies on santonin and sesquiterpene lactones as there has been little research carried out with A .…”
Section: Discussionmentioning
confidence: 99%
“…If the collection of these plants is not standardized then the results obtained may not give a true value or the desired outcome. In the case of santonin, the content is at a maximum when the flowering dried tops of the plants are collected at full bloom [ 5 ], also an important factor to be considered when preparing any effective veterinary medicine with minimum toxic effects.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…cretacea involves maceration and percolation over aluminium oxide column with 5% methanol in chloroform. The concentrated extract is exhaustively extracted with boiling water and the aqueous solutions are extracted with chloroform to yield santonin [ 106 ]. Santonin was also extracted from aerial parts of A. pallens with acetone or acetone : methanol, followed by extract fractionation on silica gel using n-hexane and hexane : acetone [ 107 , 108 ].…”
Section: Methods Of Analysis Of Sesquiterpene Lactonesmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…A rapid and simple method for the extraction and quantitative determination of santonin in Artemisia caerulescens has been established. 290 A proton and carbon NMR study of synthetic allenic derivatives of eudesmanolides and pseudoguaianolides has been reported 291 Chemical, enzymatic and microbiological means have been used in the transformation of santonin into sivasinolide and yomogin analogues. 292 The structures of the alkaline reduction products of santonin have been determined.…”
Section: Eudesmane Cycloeudesmane Lindenane and Iphionanementioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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