Sambucus ebulus - from traditional medicine to recent studies

Tasinov, Oskan; Kiselova-Kaneva, Yoana; Ivanova, Diana

doi:10.14748/ssm.v45i2.319

Cited by 17 publications

(11 citation statements)

References 35 publications

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“…In traditional Iranian medicine, it is used topically to treat in ammations caused by insect bites and also some herbs such as nettle [15,16]. It has been revealed that leaf extract of SE had an inhibitory effect on in ammatory cytokines IL-1 (IL-1α & IL-1 ) and TNF-α [17]. Moreover, other studies revealed that SE contains several compounds, including phenolic acids, avonoids, steroid, vitamin C, caffeic acid, anthocyanins and cyanogen lycosides [18,19].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

Faghani¹,

Pourgholamali²,

Ansar³

et al. 2020

Preprint

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Background: The Sambucus Ebulus (ES) L. has an anti-inflammatory role by reducing the expression of pro-inflammatory genes and free radicals. The aim of this study was to evaluate the anti-inflammatory effect of hydroalcoholic extract of SE fruits on eosinophilic nasal polyposis (NP) in Vitro.Method: The chemical composition of SE fruits extract was determined by gas chromatography-mass spectrometry. Polyp Samples were collected from 40 patients and were cut into four pieces (control and case groups). Tissue fragments were treated with 0 (control), 50, 315 and 1000µg/ml of SE FRUIT extract in a culture medium for 24 hours. Apoptosis was detected by TUNEL reaction reagent. Real time-PCR was employed to evaluate the expression of Bax and Bad genes. ELISA was used for assay of IL-5 and GM-CSF.Results: Our findings showed SE fruits extract increased apoptosis in nasal polyp tissues compared to the control group (P<0.001). Also, GM-CSF level in the experimental groups was significantly lower than that in the control group (P<0.001). In contrast, the level of IL-5 was not significantly different in the treatment and control groups (P>0.05). Bax and Bad expression showed a significant increase in the experimental groups compared to the control group (P<0.001).Conclusion: Our findings showed that SE fruits hydroalcoholic extract ameliorates NP trough elevation of apoptosis and reduction of inflammatory markers. Our experimental data revealed that SE fruits extract plays an important role in the treatment of nasal polyp through inducing apoptosis and reducing the survival of inflammatory cells.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

Faghani¹,

Pourgholamali²,

Ansar³

et al. 2020

Preprint

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“…Polyphenol preparations and polyphenol-rich extracts have also the potential to improve lipid profile [174][175][176][177]. As it was already mentioned, S. ebulus fruits are a rich source of polyphenols and especially of anthocyanins [33,108]. Also, it was found that the aqueous and aqueous alcoholic extracts of agrimony have a high polyphenol content [25,178], although their exact polyphenol composition has not yet been identified.…”

Section: Plants That Affect Lipid Metabolismmentioning

confidence: 99%

Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

Nashar¹,

Kiselova-Kaneva²,

Ivanova³

2019

Nutrition in Health and Disease - Our Challenges Now and Forthcoming Time

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The idea of this chapter is that currently available antidiabetic drugs specifically target several points of the T2D pathophysiology but they do not cover all aspects of the disease. In addition, many adverse effects of synthetic antidiabetic agents have been reported. The suggested manuscript is an overview of the available scientific literature focused on antiobesity and antidiabetic potential of selected 42 medicinal and edible plants of the Bulgarian flora. Most of the reports reveal the effect of extracts or their active components on specific biochemical mechanisms. Mechanistic data about hypoglycemic and hypolipidemic action are presented for some of the plants. An essential part of this review is dedicated to the target mechanisms behind the effects of the selected plant species. The authors hope that this review will serve as a starting point for future investigations with a contribution to the prevention and therapy of diabetes.

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“…It is known as 'Palemʼ or 'Aghtii' in Iran and distributed in Northern coast of Caspian Sea like Mazandaran province (6). Flavonoids, phenols, steroids, tannins, sambunigrin, glycosides, cardiac glycosides, caffeic acid derivatives, chlorogenic acid, ursolic acid, ebulitins, ebulin and volatile substances of these species were previously reported (6)(7)(8). In traditional medicine, extracts of different parts of the herb like leaves, rhizome, root and fruitsused in treating some inflammatory cases such as, bee and nettle bites, arthritis and sore-throat, burns and infectious wounds, edema, eczema, urticaria, hemorrhoids, rheumatism (6,7,9).…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoids, phenols, steroids, tannins, sambunigrin, glycosides, cardiac glycosides, caffeic acid derivatives, chlorogenic acid, ursolic acid, ebulitins, ebulin and volatile substances of these species were previously reported (6)(7)(8). In traditional medicine, extracts of different parts of the herb like leaves, rhizome, root and fruitsused in treating some inflammatory cases such as, bee and nettle bites, arthritis and sore-throat, burns and infectious wounds, edema, eczema, urticaria, hemorrhoids, rheumatism (6,7,9). In other studies some effects of S. ebulus were investigated Anti-inflammatory and antinociceptive (10), antioxidant (11,12) anticancer (13) and antibacterial (14) effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sambucus ebulus topical preparation on uremic pruritus

et al. 2017

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Uremic pruritus is a common and distressing symptom that affects more than 40% of patients undergoing hemodialysis. Several medications as well as topical preparation have been used for relief this condition. Sambucus ebulus has been shown antiinflammatory and wound healing effects. In this research, the antipruritic effect of S. ebulus fruit extract was evaluated on patients with uremic pruritus. S. ebulus fruits were collected from Sari suburb, Iran. Fruits were dried at room temperature and several fractions of extract were prepared. After formulating suitable gel (2%) a randomized, single blind, placebo-controlled clinical trial was performed in 78 patients (40 patients received S. ebulus topical gel 2% and 38 patients received placebo gel) for 8 weeks and the changes in hyperuremic induced pruritus severity were evaluated. Sixty one patients completed the study. The Pruritus severity index was reduced in both groups after 8 weeks' treatment. S. ebulus topical gel showed more effect than placebo, but this difference was not statistically significant. The results showed that S. ebulus topical gel can reduce uremic pruritus severity, and more study with higher extract concentration or more cases is proposed.

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Sambucus ebulus - from traditional medicine to recent studies

Cited by 17 publications

References 35 publications

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

Effect of Sambucus ebulus topical preparation on uremic pruritus

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