Salzmann's Corneal Degeneration Associated with Epithelial Basement Membrane Dystrophy

Werner, L; Issid, K; Pouliquen, Y; Jm, Legeais; Renard, G

doi:10.1097/00003226-200001000-00024

Cited by 17 publications

(12 citation statements)

References 8 publications

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“…3 Ocular histories of surgery, trauma, and exposure keratitis have also been reported in association with Salzmann's nodular degeneration. 4 Rarely, noninflammatory conditions such as filamentary keratitis, corneal epithelial basement membrane dystrophy, hard contact lens wear, and keratoconus have been associated with Salzmann's nodular degeneration as well. 3 Some cases appear to be inherited in an autosomal dominant fashion, whereas many other cases appear to be idiopathic.…”

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“…1 When patients do experience symptoms, the majority are related to recurrent corneal erosions. 3,4 Common symptoms include decreased visual acuity (VA) and blepharospasm. 3,4 Decreased VA can be caused by an irregular astigmatism or corneal scar produced in Salzmann's nodular degeneration.…”

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“…3,4 Common symptoms include decreased visual acuity (VA) and blepharospasm. 3,4 Decreased VA can be caused by an irregular astigmatism or corneal scar produced in Salzmann's nodular degeneration. 5 Common dry-eye symptoms such as pain, foreign-body sensation, and photophobia may also occur.…”

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“…5 Common dry-eye symptoms such as pain, foreign-body sensation, and photophobia may also occur. 3,4,6 Ocular surgeries, including corneal surgeries, have been found to increase the risk for developing Salzmann's nodular degeneration. 3,4 The ophthalmic literature, however, contains no reports of the correlation between patients who have had laser in situ keratomileusis (LASIK) surgery and the later appearance of Salzmann's nodular degeneration.…”

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Salzmann's-like nodular degeneration following laser in situ keratomileusis

Moshirfar

Marx²,

Barsam³

et al. 2005

Journal of Cataract and Refractive Surgery

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We report the development of bilateral Salzmann's-like corneal lesions located at the site of laser in situ keratomileusis (LASIK) flap margins in 2 patients. These lesions resulted in ocular surface irritation as well as induction of irregular astigmatism and associated loss of best corrected visual acuity. Both patients had bilateral LASIK before the occurrence of the corneal lesions. A biopsy was performed on 1 nodule. The epithelium overlying this raised bluish-white corneal lesion appeared irregular in thickness, with replacement of Bowman's layer by periodic acid-Schiff positive thickened basement membrane-like material. Underlying this basement membrane was a layer of relatively regular, hypocellular, collagenlike connective tissue, which demonstrated hyalinization on trichrome staining. Based on these 2 cases, it seems possible that the hyposecretion of tears, decreased blink rate, and Dellen effect that often occur following LASIK could produce the corneal irritation needed to induce Salzmann's nodular degeneration.

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confidence: 99%

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Salzmann's-like nodular degeneration following laser in situ keratomileusis

Moshirfar

Marx²,

Barsam³

et al. 2005

Journal of Cataract and Refractive Surgery

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“…[33,42] und zu dem Rat geführt hat, in diesen Familien das TGFBI-Gen (s. oben) zu untersuchen [20]. In Einzelfällen ist die Kombination eines Salzmann mit einer anderen Hornhautdystrophie des gleichen Zellursprungs, der epithelialen Basalmembrandystrophie, beschrieben worden [51,53].…”

Section: Nachweis Aktivierter Epithelien üBer Den Knötchen In Zellmarunclassified

Salzmannsche noduläre Hornhautdegeneration

Sundmacher

2012

Ophthalmologe

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So-called Salzmann's nodular degeneration has been given a misleading position in the systematics of ophthalmology. The majority of cases of Salzmann's nodular degeneration are in fact a clinical entity fulfilling the criteria of epithelial corneal dystrophy involving Bowman's layer. As with all epithelial dystrophies Salzmann's nodular degeneration recurs after surgical removal. An analysis of Salzmann's original paper discloses that the etiological postulates (severe preceding keratitis, especially phlyctenular keratitis) have never been substantiated by direct observation but only suspected by indirect histopathological circumstantial evidence. This has long lost credibility and should never have been taken for real evidence. However, degenerative types of Salzmann's nodular degeneration besides the dystrophic type still exist but the etiology and pathogenesis of these degenerative types have not yet been sufficiently described. No distinction has been made in studies of Salzmann's nodular degeneration up to now between dystrophic and degenerative types which could render such publications worthless on re-evaluation. While therapy of Salzmann's dystrophy is usually simple even after recurrence this may be different with the degenerative forms. The many questions and inconsistencies which have long been noted with "Salzmann's degeneration" as it has been misunderstood, can only be answered and solved if dystrophy and degeneration are investigated separately in future studies.

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Corneal and Conjunctival Degenerations

Chang¹,

Ching²

2011

Cornea

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Salzmann's Corneal Degeneration Associated with Epithelial Basement Membrane Dystrophy

Cited by 17 publications

References 8 publications

Salzmann's-like nodular degeneration following laser in situ keratomileusis

Salzmann's-like nodular degeneration following laser in situ keratomileusis

Salzmannsche noduläre Hornhautdegeneration

Corneal and Conjunctival Degenerations

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