2020
DOI: 10.3892/etm.2020.9020
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Abstract: Liver injury occurs frequently during sepsis, which leads to high mortality and morbidity. A previous study has suggested that salvianolic acid B (SalB) is protective against sepsis-induced lung injury. However, whether SalB is able to protect against sepsis-induced liver injury remains unclear. The present study aimed to investigate the effects of SalB on sepsis-induced liver injury and its potential underlying mechanisms. Sepsis was induced in mice using a cecal ligation and puncture (CLP) method. The mice w… Show more

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Cited by 13 publications
(21 citation statements)
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“…Our results showed that neither meldonium nor treatments significantly altered PGC1-α protein level in any of the examined tissues ( Figure 5 ), in contrast to studies on different models of sepsis showing a reduction of PGC1-α content in the heart, kidney, and liver [ 76 , 77 , 78 , 79 ]. Since the proposed mechanism of PGC1-α downregulation under the septic conditions includes NF-kB activation [ 80 , 81 ], which we did observe, the supposed inconsistency between our results and those previously published could be explained by the difference in the experimental designs.…”
Section: Resultscontrasting
confidence: 92%
See 1 more Smart Citation
“…Our results showed that neither meldonium nor treatments significantly altered PGC1-α protein level in any of the examined tissues ( Figure 5 ), in contrast to studies on different models of sepsis showing a reduction of PGC1-α content in the heart, kidney, and liver [ 76 , 77 , 78 , 79 ]. Since the proposed mechanism of PGC1-α downregulation under the septic conditions includes NF-kB activation [ 80 , 81 ], which we did observe, the supposed inconsistency between our results and those previously published could be explained by the difference in the experimental designs.…”
Section: Resultscontrasting
confidence: 92%
“…Since the proposed mechanism of PGC1-α downregulation under the septic conditions includes NF-kB activation [ 80 , 81 ], which we did observe, the supposed inconsistency between our results and those previously published could be explained by the difference in the experimental designs. Specifically, the experimental design mentioned in the literature implied tissue collection 12–72 h following the sepsis induction [ 76 , 77 , 78 , 79 ]. In contrast, we collected organs as early as within 8–9 h due to the high mortality rate following FIP injection.…”
Section: Resultsmentioning
confidence: 99%
“… 41 Moreover, Sal B reduces inflammation and hepatocyte apoptosis by activating the SIRT1/PGC-1α signaling pathway to attenuate liver damage caused by sepsis. 42 In addition, Sal B is recognized to prominently alleviate liver fibrosis in chronic hepatitis B virus (HBV) patients without causing obvious side effects. 41 Furthermore, Sal B protects the integrity of the lysosomal membrane by up-regulating the expression of LAMP1, thereby reducing the leakage of CatB/D into the cytosol and protecting hepatocytes from death.…”
Section: Discussionmentioning
confidence: 99%
“…Regarding its effects on the hepatic system, salvianolic acid B suppresses hepatic endoplasmic reticulum stress to improve insulin resistance in ob/ob mice (Shi et al 2020 ). Salvianolic acid B also blocks the activation of hepatic stellate cells, protects against sepsis-induced liver injury, and prevents and alleviates liver, pulmonary and renal interstitial fibrosis (Su et al 2020 ; Ma et al 2020 ; Jiang et al 2020a ; Hu et al 2020b ; Tian et al 2021 ; Gong et al 2021 ). Furthermore, salvianolic acid B prevents high-fat diet-induced obese mice body weight gain and regulates gut microbiota (Li et al 2020b ).…”
Section: Trpcs Antagonistsmentioning
confidence: 99%