Salvianolic acid B prevents body weight gain and regulates gut microbiota and LPS/TLR4 signaling pathway in high-fat diet-induced obese mice

Li, Lin; Li, Rui; Zhu, Ruyuan; Chen, Beibei; Tian, Yimiao; Zhang, Hao; Xia, Bingke; Jia, Qiangqiang; Wang, Lili; Zhao, Dandan; Mo, Fangfang; Yu, Li; Zhang, Shujing; S, Gao; Zhang, Dongwei; Guo, Shuzhen

doi:10.1039/d0fo01116a

Cited by 39 publications

(31 citation statements)

References 50 publications

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“…F16 was also identified as novel superior microbiota in probiotics intervention groups, which was consistent with a previous study (39). Based on LEfSe analysis, the genera Oscillospira, Lactococcus, and Mucispirillum, which were the characteristic flora of the HFD group, were found to be positively correlated to the LPS, suggesting that these bacteria may play a pro-inflammatory role in the development of obesity and IR (37,40). It was also speculated whether the disorder of glycolipid metabolism could be modified by the beneficial gut microbes by preventing inflammation.…”

Section: Discussionsupporting

confidence: 88%

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

et al. 2021

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Lactobacillus plantarum ZJUFB2 is a novel probiotic isolate derived from Chinese traditional sourdough that possesses promising probiotics properties. This study aimed to investigate the effects of L. plantarum ZJUFB2 (B2) on insulin sensitivity using mice fed on a high-fat diet (HFD) as well as to explore the involved mechanisms. Purposely, male C57BL/6 mice continuously received an intervention of B2 (~109 CFU/day) for 16 weeks. The results showed that B2 treatment remarkably ameliorated insulin resistance and hyperglycemia in HFD-fed mice. The B2 intervention significantly decreased the hepatic lipid accumulation, serum low-density lipoproteins cholesterol, and lipopolysaccharides, and regulated the bile acids levels as well as liver mRNA expression involved in lipid metabolism. Moreover, the B2 intervention significantly changed the gut microbiota, specifically, showed a lower abundance of obesity-related and inflammation-associated microbes, e.g., Ruminococcus and Mogibacteriaceae. Furthermore, it exhibited a higher abundance of short-chain fatty acids and bile salt hydrolas-producing bacteria, such as Bifidobacterium and F16 compared with the HFD group. The findings of this study suggested that B2 is a novel probiotic, effective in preventing insulin resistance by improving the gut microbiota and bile acids.

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Section: Discussionsupporting

confidence: 88%

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

et al. 2021

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“…LPS, the main component of outer membrane of Gram-negative bacteria, is believed to be enriched by gut microbiota [ 52 ]. Serum LPS content can reflect the change of intestinal permeability, and then reflect the level of gut microbiota disorders [ 53 ]. HFD feeding can promote the proliferation of endotoxin-producing bacteria [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Zhao

Hou

et al. 2021

Nutrients

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Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki bean (HFD-AB) for 12 weeks. Adzuki bean supplementation significantly reduced obesity, lipid accumulation, and serum lipid and lipopolysaccharide (LPS) levels induced by HFD. It also mitigated liver function damage and hepatic steatosis. In particular, adzuki bean supplementation improved glucose homeostasis by increasing insulin sensitivity. In addition, it significantly reversed HFD-induced gut microbiota imbalances. Adzuki bean significantly reduced the ratio of Firmicutes/Bacteroidetes (F/B); enriched the occurrence of Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, and Lachnoclostridium; and returned HFD-dependent taxa (Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, and Ruminiclostridium) back to normal status. PICRUSt2 analysis showed that the changes in gut microbiota induced by adzuki bean supplementation may be associated with the metabolism of carbohydrates, lipids, sulfur, and cysteine and methionine; and LPS biosynthesis; and valine, leucine, and isoleucine degradation.

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“…Studies have shown that salvianolic acid A in Salvia miltiorrhiza can inhibit the oxidation of LDL, inhibit inflammation, and improve endothelial function to ameliorate AS [ 135 , 136 ]. Salvianolic acid B (Sal B) can reverse gram-negative bacteria in HFD mice, which is positively associated with LPS elevation and increases the abundance of adlercreutzia to improve gut permeability [ 116 ]. By maintaining intestinal motility, Salvia miltiorrhiza could improve the tolerance of intestinal mucosal epithelial cells to ischaemia and hypoxia to protect intestinal barrier function [ 117 ].…”

Section: Therapeutic Intervention With Tcmmentioning

confidence: 99%

“…Thus, Salvia miltiorrhiza can reduce metabolic endotoxaemia by reducing LPS and protecting the intestinal barrier. Furthermore, in Lin's study [ 116 ], salvianolic acid B inhibited the LPS/TLR4 signalling pathway by inhibiting the abundance of gram-negative bacteria and improving insulin sensitivity and lipid metabolism disorder in HFD mice.…”

Section: Therapeutic Intervention With Tcmmentioning

confidence: 99%

Gut microbiota: a potential target for traditional Chinese medicine intervention in coronary heart disease

Cheng

Chen

et al. 2021

Chin Med

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Coronary heart disease (CHD) is a common ischaemic heart disease whose pathological mechanism has not been fully elucidated. Single target drugs, such as antiplatelet aggregation, coronary artery dilation and lipid-lowering medicines, can relieve some symptoms clinically but cannot effectively prevent and treat CHD. Accumulating evidence has revealed that alterations in GM composition, diversity, and richness are associated with the risk of CHD. The metabolites of the gut microbiota (GM), including trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs) and bile acids (BAs), affect human physiology by activating numerous signalling pathways. Due to the advantage of multiple components and multiple targets, traditional Chinese medicine (TCM) can intervene in CHD by regulating the composition of the GM, reducing TMAO, increasing SCFAs and other CHD interventions. We have searched PubMed, Web of science, Google Scholar Science Direct, and China National Knowledge Infrastructure (CNKI), with the use of the keywords “gut microbiota, gut flora, traditional Chinese medicine, herbal medicine, coronary heart disease”. This review investigated the relationship between GM and CHD, as well as the intervention of TCM in CHD and GM, and aims to provide valuable insights for the treatments of CHD by TCM.

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Salvianolic acid B prevents body weight gain and regulates gut microbiota and LPS/TLR4 signaling pathway in high-fat diet-induced obese mice

Abstract: Salvianolic acid B (Sal B) exhibits an anti-obesity activity, yet the underlying mechanism linking this effect to metabolic endotoxemia remains unexploited. For this purpose, high-fat diet-induced obese mice were orally...

Cited by 39 publications

References 50 publications

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Gut microbiota: a potential target for traditional Chinese medicine intervention in coronary heart disease

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