Salvianolic acid B alleviates neurological injury by upregulating stanniocalcin 1 expression

Bi, Shao‐Jie; Dong, Xin-Ying; Wang, Ze-Ying; Fu, Shanji; Li, Changling; Wang, Zhaoyang; Xie, Fei; Chen, Xueying; Xu, Hao; Cai, Xiaojun; Zhang, Mingxiang

doi:10.21037/atm-21-4779

Cited by 10 publications

(8 citation statements)

References 33 publications

(51 reference statements)

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“…26 Increasing the expression of STC1 can promote angiogenesis and reduce neuronal apoptosis. 27 However, the impact of STC1 on the blood−brain barrier remains unclear. 28,29 A prospective cohort study found that the serum concentrations of STC1 were increased in intracerebral hemorrhage patients and independently predicted a poor prognosis.…”

Section: ■ Discussionmentioning

confidence: 99%

“…There is a lack of clinical research on the association of STC1 with IS, but preclinical studies suggest that it is involved in neuroprotection after ischemia, thereby participating in functional recovery after IS . Increasing the expression of STC1 can promote angiogenesis and reduce neuronal apoptosis . However, the impact of STC1 on the blood–brain barrier remains unclear. , A prospective cohort study found that the serum concentrations of STC1 were increased in intracerebral hemorrhage patients and independently predicted a poor prognosis .…”

Section: Discussionmentioning

confidence: 99%

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Serum Olink Proteomics-Based Identification of Protein Biomarkers Associated with the Immune Response in Ischemic Stroke

Zhao,

Zeng,

Zhang

et al. 2024

J. Proteome Res.

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The immune response is considered essential for pathology of ischemic stroke (IS), but it remains unclear which immune response-related proteins exhibit altered expression in IS patients. Here, we used Olink proteomics to examine the expression levels of 92 immune response-related proteins in the sera of IS patients (n = 88) and controls (n = 88), and we found that 59 of these proteins were differentially expressed. Feature variables were screened from the differentially expressed proteins by the least absolute shrinkage and selection operator (LASSO) and the random forest and by determining whether their proteins had an area under the curve (AUC) greater than 0.8. Ultimately, we identified six potential protein biomarkers of IS, namely, MASP1, STC1, HCLS1, CLEC4D, PTH1R, and PIK3AP1, and established a logistic regression model that used these proteins to diagnose IS. The AUCs of the models in the internal validation and the test set were 0.962 (95% confidence interval (CI): 0.895−1.000) and 0.954 (95% CI: 0.884−1.000), respectively, and the same protein detection method was performed in an external independent validation set (AUC: 0.857 (95% CI: 0.801−0.913)). These proteins may play a role in immune regulation via the C-type lectin receptor signaling pathway, the PI3K−AKT signaling pathway, and the B-cell receptor signaling pathway.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Olink Proteomics-Based Identification of Protein Biomarkers Associated with the Immune Response in Ischemic Stroke

Zhao,

Zeng,

Zhang

et al. 2024

J. Proteome Res.

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“…The above results suggest that there is a close relationship between neurons and ECs in the process of angiogenesis, and angiogenesis often promotes the recovery of neurological function after cerebral ischemia. Moreover, studies report that postischemic angiogenesis follows a temporal course (Bi et al., 2022; Zhang et al., 2009). ECs begin mitosis as early as 1 day after mouse cerebral reperfusion after 30 min of MCAO, and the number of vessels begins to significantly increase on the 3 days before peaking at 7 days after stroke (Yang et al., 2016).…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture reverses endothelial cell death and promotes angiogenesis through the VEGF/Notch signaling pathway after focal cerebral ischemia‐reperfusion injury

et al. 2023

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Background Angiogenesis is an important mechanism of recovery from ischemic stroke. Recent studies have found that there is a close relationship between the VEGF/Notch pathway and angiogenesis. It is unknown whether EA can exert a brain protection effect and promote angiogenesis by acting on the VEGF/Notch signaling pathway after focal cerebral ischemia‐reperfusion injury (CIRI). Methods The Middle Cerebral Artery occlusion/Reperfusion (MCAo/R) model was established, in which rats were subjected to occlusion with ischemic intervention for 30 min, followed by reperfusion for 8 h, 1 day, 3 days, and 7 days. The first EA treatment was performed 90 min after the animal model was successfully established, and then EA treatments were performed once a day for 7 days. The 2,3,5‐triphenyltetrazolium chloride staining and neurological deficit examination were performed to assess the level of CIRI and neuroprotection by EA. Expression levels of VEGFA, Notch1, and Hes1 proteins were measured via western blotting, while the morphological changes of ECs and microvasculature in the cortex were determined using an ultrastructural observation method. Results EA treatment of PC6, GV26, and SP6 can significantly improve the neurological function of MCAO/R rats, reduce the volume of cerebral infarction, and modulate the ultrastructure of ECs and microvessels in pathological states. Western blotting revealed that EA increased VEGFA protein expression at 8 h and 3 days after CIRI, as well as Notch1 protein expression at 1 and 7 days. Subsequently, EA activated the VEGF/Notch pathway, increasing the expression of the downstream target protein Hes1, reversing EC death, and promoting angiogenesis. Conclusion Our findings showed that EA plays a role in promoting angiogenesis following focal CIRI, and we hypothesized that this was due to the regulation of ECs by the EA‐activated VEGF/Notch signaling pathway.

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“…In an experiment on middle cerebral artery occlusion-induced ischemic stroke rats, salvianolic acid B attenuated ischemic brain injury and neurological injury by increasing stanniocalcin 1 (STC1), thus inducing Akt/mTOR phosphorylation and the upregulation of VEGF and VEGF receptor 2 (VEGFR2), which promoted angiogenesis and protected against neuronal apoptosis [ 56 ]. In addition, salvianolic acid B can enhance the autophagic activity of astrocytes by activating the adenosine 5′-monophosphate-activated protein kinase (AMPK)/mTOR/Unc-51-like kinase 1 (ULK1) signaling pathway and promoting the autophagic degradation of pS757-ULK1, thus playing a neuroprotective role in cerebral ischemic injury.…”

Section: Pharmacological Effectsmentioning

confidence: 99%

Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes

He,

Chen,

Liu

et al. 2023

Pharmaceutics

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Salvianolic acid B is extracted from the roots and rhizomes of Danshen (Salvia miltiorrhiza Bge., family Labiatae). It is a water-soluble, weakly acidic drug that has demonstrated antitumor and anti-inflammatory effects on various organs and tissues such as the lung, heart, kidney, intestine, bone, liver, and skin and protective effects in diseases such as depression and spinal cord injury. The mechanisms underlying the protective effects of salvianolic acid B are mainly related to its anti-inflammatory, antioxidant, anti- or pro-apoptotic, anti- or pro-autophagy, anti-fibrotic, and metabolism-regulating functions. Salvianolic acid B can regulate various signaling pathways, cells, and molecules to achieve maximum therapeutic effects. This review summarizes the safety profile, combination therapy potential, and new dosage forms and delivery routes of salvianolic acid B. Although significant research progress has been made, more in-depth pharmacological studies are warranted to identify the mechanism of action, related signaling pathways, more suitable combination drugs, more effective dosage forms, and novel routes of administration of salvianolic acid B.

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Salvianolic acid B alleviates neurological injury by upregulating stanniocalcin 1 expression

Cited by 10 publications

References 33 publications

Serum Olink Proteomics-Based Identification of Protein Biomarkers Associated with the Immune Response in Ischemic Stroke

Serum Olink Proteomics-Based Identification of Protein Biomarkers Associated with the Immune Response in Ischemic Stroke

Electroacupuncture reverses endothelial cell death and promotes angiogenesis through the VEGF/Notch signaling pathway after focal cerebral ischemia‐reperfusion injury

Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes

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