volume 9, issue 1, P156-172 2016
DOI: 10.18632/aging.101145
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Ying Xu, Ting Chen, Xin Li, Ya-kun Qu, Jin-na An, Hong-xia Zheng, Zi-jia Zhang, Na Lin

Abstract: Salvia miltiorrhiza bunge (SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in vitro studies focusing on the estrogen receptor (ER) pathway for further molecular characterizations. SM treatments demonstrated significant estrogenic activity by promoting the development of ut…

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