Salvia miltiorrhiza: An Economically and Academically Important Medicinal Plant

Lu, Shanfa

doi:10.1007/978-3-030-24716-4_1

Cited by 7 publications

(2 citation statements)

References 91 publications

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“…The characteristic orange–red pigment in Danshen is mainly composed of numerous nor-diterpenoid tanshinones, some of them being primary bioactive ingredients, such as cryptotanshinone, tanshinone I, tanshinone IIA, and tanshinone IIB [ 7 ], which are mainly synthesized and accumulated in the periderm of the root of S. miltiorrhiza [ 8 , 9 ]. The redder the color in the root with a specific diameter, the higher the tanshinone content.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis in Salvia miltiorrhiza Roots

Lin

Zhang

et al. 2022

IJMS

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Tanshinones are the bioactive constituents of Danshen (Salvia miltiorrhiza Bunge), which is used in Traditional Chinese Medicine to treat cardiovascular and other diseases, and they synthesize and accumulate in the root periderm of S. miltiorrhiza. However, there is no relevant report on the initial stage of tanshinone synthesis, as well as the root structure and gene expression characteristics. The present study aims to provide new insights into how these bioactive principles begin to synthesize by characterizing possible differences in their biosynthesis and accumulation during early root development from both spatial and temporal aspects. The morphological characteristics and the content of tanshinones in roots of S. miltiorrhiza were investigated in detail by monitoring the seedlings within 65 days after germination (DAGs). The ONT transcriptome sequencing was applied to investigate gene expression patterns. The periderm of the S. miltiorrhiza storage taproot initially synthesized tanshinone on about 30 DAGs. Three critical stages of tanshinone synthesis were preliminarily determined: preparation, the initial synthesis, and the continuous rapid synthesis. The difference of taproots in the first two stages was the smallest, and the differentially expressed genes (DEGs) were mainly enriched in terpene synthesis. Most genes involved in tanshinone synthesis were up regulated during the gradual formation of the red taproot. Plant hormone signal transduction and ABC transport pathways were widely involved in S. miltiorrhiza taproot development. Five candidate genes that may participate in or regulate tanshinone synthesis were screened according to the co-expression pattern. Moreover, photosynthetic ferredoxin (FD), cytochrome P450 reductase (CPR), and CCAAT binding transcription factor (CBF) were predicted to interact with the known downstream essential enzyme genes directly. The above results provide a necessary basis for analyzing the initial synthesis and regulation mechanism of Tanshinones.

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Section: Introductionmentioning

confidence: 99%

Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis in Salvia miltiorrhiza Roots

Lin

Zhang

et al. 2022

IJMS

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“…Over 10% of traditional Chinese patent medicines and simple preparations contain S. miltiorrhiza. The annual consumption of S. miltiorrhiza has exceeded 16 million kilograms in China [18]. With the increased demand for S. miltiorrhiza, wild resources are gradually being exhausted and the cultivation of new resources has become a research hotspot.…”

Section: Introductionmentioning

confidence: 99%

The Ethylene Response factor SmERF1 Improves Salinity Tolerance and Impacts Seed Size in Tobacco

Hua¹,

Chen²,

Kong³

et al. 2020

Preprint

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Background Ethylene response factor (ERF) proteins play vital roles in plant resistance and plant development. However, little is known about the ERF transcription factors of Salvia miltiorrhiza, which is a famous Chinese herb with good resistance to stress. Result Screened from our previous transcriptome data, SmERF1, an ERF transcript factor, was isolated from S. miltiorrhiza. SmERF1 had a single AP domain and was classified in the ERF E3 subfamily. SmERF1-expressing tobacco plants showed slower growth, less biomass and a decrease in chlorophyll only at the seedling stage, and there was no significant difference in other growth stages. In addition, seeds of tobacco plants with SmERF1 expression were smaller and lighter than those of wild plants, similar to some AP2 TFs. Under NaCl treatment, transgenic tobacco lines showed better tolerance to salinity, and the proline content, SOD and POD activities of transgenic lines were higher than those of wild-type plants, while MDA content was lower than that of wild-type plants. Furthermore, we determined the phytohormones related to plant resistance and showed that transgenic tobacco plants had higher ABA levels and lower GA levels than wild tobacco. The expression of SmERF1 regulated the expression of key enzyme genes related to plant hormone biosynthesis, such as NtSDR, NtGA20ox, NtACO and NtACS. Conclusions The SmERF1-expression in tobacco affect plant growth at seedling stage, and increase plant tolerance to salt. And the expression of SmERF1 cause tobacco seeds smaller and lighter. Our study suggested that SmERF1 enhanced tobacco tolerance to salt and impacted seed size through an ABA-dependent pathway.

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Biosynthesis and Regulatory Mechanisms of Bioactive Compounds in Salvia miltiorrhiza, a Model System for Medicinal Plant Biology

2021

Critical Reviews in Plant Sciences

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Salvia miltiorrhiza: An Economically and Academically Important Medicinal Plant

Cited by 7 publications

References 91 publications

Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis in Salvia miltiorrhiza Roots

Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis in Salvia miltiorrhiza Roots

The Ethylene Response factor SmERF1 Improves Salinity Tolerance and Impacts Seed Size in Tobacco

Biosynthesis and Regulatory Mechanisms of Bioactive Compounds in Salvia miltiorrhiza, a Model System for Medicinal Plant Biology

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