Salvage Surgery After Radiotherapy for Laryngeal Cancer

Limitations and Opportunities in Open Laryngeal Organ Preservation Surgery: Current Role of OPHLs

“…Pellini et al reported an “acceptable quality of voice for most patients” (82), very perturbed and hoarse in the majority of patients with maximum phonation time (MPT) ranging from 3 to 18 s (mean, 8.3 s). Similar results were also reported by several other authors (83, 85, 87) (Table 2).…”

Salvage Transoral Laser Microsurgery for Radiorecurrent Laryngeal Cancer: Indications, Limits, and Outcomes

“…The series of Puxeddu et al [15] is a two-center retrospective case series, with results of one included center updated in a later publication by Piazza et al [16], which, in turn, was updated by Del Bon et al [17]. Most authors reported on series of rT1 to rT2 glottic cancer, while some authors also included more advanced glottic cases (rT3 or even rT4) [11••, 18–21] or supraglottic recurrences [14, 18, 20–22].…”

“…When compared to open partial laryngeal surgery techniques, salvage TLM as a treatment modality for radiorecurrent laryngeal cancer combines good oncologic outcomes with the advantages of reduced complications, better functional outcomes in terms of voice and swallowing (lesser rates of tracheostomy and tube feeding), shortened hospitalization time, and superior cost-effectiveness [7, 16]. However, a trend towards inferior local control rates, even after repeat TLM, when compared to open partial laryngectomy techniques, was demonstrated in a recent systematic review and meta-analysis by Ramakrishnan et al [8••].…”

Factors Associated with Outcomes Following Salvage Surgery for Recurrent Laryngeal Cancer: A Retrospective Study of 50 Cases from a Single Center in Poland

“…It should be added that local and nodal staging at the time of cancer diagnosis is one of the factors affecting the results of salvage surgery in patients with recurrence after oncological treatment [ 5 , 8 , 16 , 20 , 25 , 27 , 36 , 37 ]. For example, Davidson et al reported a 3-year OS rate of only 22% in 108 patients with advanced laryngopharyngeal carcinoma who underwent salvage treatment after failed radiation therapy [ 36 ].…”