Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort

Ferraris, Celeste; Turner, Alexandria; Kaur, Kiranjit; Piper, Jessica; Veysey, Martin; Lucock, Mark; Beckett, Emma L.

doi:10.3390/nu12041056

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…The association between salt intake and blood pressure is addressed in this Special Issue. Ferraris et al [6] found (see above) that SNP for the gene encoding the salt receptor, TRPV1, was not associated with a variation in salt intake in an elderly cohort. Consistently, neither systolic nor diastolic blood pressure varied by genotype.…”

Section: Blood Pressure Regulationmentioning

confidence: 99%

“…Thus, oral microbiota may influence food preference. The possible association between salt taste genotype and eating behavior has been studied by Ferraris et al [6] in a large-sized (n = 536) and well-characterized elderly cohort in Australia. They evaluated the association between the occurrence of single nucleotide polymorphisms (SNPs) for the TRPV1-encoding gene and individual salt intake.…”

Section: Eating Behaviormentioning

confidence: 99%

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Salt Taste, Nutrition, and Health

Bigiani

2020

Nutrients

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Section: Blood Pressure Regulationmentioning

confidence: 99%

Section: Eating Behaviormentioning

confidence: 99%

Salt Taste, Nutrition, and Health

Bigiani

2020

Nutrients

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“…DNA samples were stored at 20 °C prior to genotyping. Genotyping was carried out via qPCR (QuantStudio 7 Flex Real-Time PCR) with TaqMan™ SNP Genotyping Assays (Applied Biosystems™, ThermoFisher Scientific, CA, USA) and TaqMan™ Genotyping Master Mix according to the TaqMan™ user guide [ 56 , 57 ]. Participants were included in this study only upon successful genotyping.…”

Section: Methodsmentioning

confidence: 99%

Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort

et al. 2021

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Globally, more than one-third of adults are overweight. Overweight and obesity are complex and multifaceted conditions, associated with an increased risk of chronic illness and early mortality. While there are known risk factors, these alone do not fully explain the varying outcomes between individuals. Recently, taste receptors have been proposed to have a role in the risk for obesity. These receptors are expressed throughout the gastrointestinal tract. In this system, they may be involved in modulating dietary intake and metabolic processes. The taste 2 family of receptors (T2Rs) detects bitter compounds. Receptors T2R4 and T2R5 detect (-)-epicatechin (epicatechin), an antioxidant polyphenol, which may have protective effects against obesity. However, the potential role for taste receptors in this association has not been explored. This study assessed whether polymorphisms in TAS2R4 (rs2233998 and rs2234001) and TAS2R5 (rs2227264) were associated with body mass index (BMI). Genotyping (Taqman qPCR assays) was performed on DNA extracted from blood samples (n = 563) from an elderly cohort. Homozygosity for the minor allele of all polymorphisms was significantly associated with a lower BMI in males. The TAS2R4-rs2233998 CC genotype, the TAS2R4-rs2234001 CC genotype and the TAS2R5-rs2227264 TT genotype were associated with lower BMI (2.1, 2.1 and 2.2 units; p = 0.002, 0.003 and 0.001, respectively). Epicatechin intake was not associated with BMI and genotype was not associated with epicatechin intake. This suggests that the association between TAS2R genotype and elevated BMI risk occurs through altered extra-oral responses and not directly via altered epicatechin intake.

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“…Demographic data (age, sex, income, education, history of smoking) were collated through interviewer-administered questionnaires (30,32,33). Body dimension (hip circumference, waist circumference, and height) and weight measurements were collected adhering to the standards of the International Society for the Advancement of Kinanthropometry (ISAK) (34).…”

Section: Demographics and Anthropometricsmentioning

confidence: 99%

“…Blood pressure (BP) measurements were taken from both arms by qualified clinical staff using an OMRON IA2 machine (32). Physical limitation preventing measurement, repetitive differences in systolic BP of >10 mmHg and diastolic BP of >6 mmHg, very high BP curtailing measurement and machine error were exclusion criteria (32). Following the World Health Organisation's guidelines, hypertensive was defined as recording systolic BP of ≥140 mmHg and diastolic BP of ≥90 mmHg (41).…”

Section: Blood Pressure Readingsmentioning

confidence: 99%

Sour Taste SNP KCNJ2-rs236514 and Differences in Nutrient Intakes and Metabolic Health Markers in the Elderly

et al. 2021

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Single nucleotide polymorphisms (SNPs) in taste receptors influence dietary choices that contribute to health and quality of life. Individual differences in sour taste perception and preference have been linked to heritable genetics, yet the impact of sour taste receptor SNPs on sour taste is under-researched, and studies on sour taste SNP associations to diet and health are lacking. Therefore, this study explored the relationships between the sour taste SNP KCNJ2-rs236514 and estimated macronutrient, vitamin and mineral intakes, and markers of metabolic health. Associations were explored in 523 participants aged 65 years and older with data analysed using standard least squares and nominal logistic regression modelling with post hoc student's t-tests and Tukey's HSD. Associations were found between the presence of the KCNJ2-rs236514 variant allele (A) and lower intakes of energy, total fat, monounsaturated fat and saturated fat. The lower fat intakes were significant in female carriers of the variant allele (A), along with lower water intake. Lower retinol, riboflavin, folate, calcium and sodium intakes were found in the KCNJ2-A allele carriers. In females, the variant allele was associated with lower sodium intake before and after Bonferroni adjustment. Higher body mass index, waist and waist-to-hip ratio measures were found in males carrying the variant allele. Lower levels of liver function biomarkers were associated with the presence of the KCNJ2-A allele. Overall and in males, the variant's association to lower gamma-glutamyl transferase (GGT) levels remained significant after Bonferroni adjustments. These novel findings suggest the sour taste SNP, KCNJ2-rs236514, may be modifying macronutrient, vitamin and mineral intakes, and markers of metabolic health. Research on the extra-oral functions of this SNP may improve health outcomes for those with overweight, obesity and liver disease.

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Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort

Cited by 9 publications

References 33 publications

Salt Taste, Nutrition, and Health

Salt Taste, Nutrition, and Health

Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort

Sour Taste SNP KCNJ2-rs236514 and Differences in Nutrient Intakes and Metabolic Health Markers in the Elderly

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